4-iodo-5-phenyl-1H-pyrazol-3-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-iodo-5-phenyl-1H-pyrazol-3-amine
• 化学式: C₉H₈IN₃
• 分子量: 285.08
• InChiKey: IFZPZVXQHIQTEM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.7
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• PYRAZOLOPYRIDAZINES AND METHODS FOR TREATING RETINAL-DEGENERATIVE DISEASES AND HEARING LOSS ASSOCIATED WITH USHER SYNDROME
  申请人：Usher III Initiative

  公开号：US20140121197A1

  公开（公告）日：2014-05-01

  Compounds, compositions and methods for the treatment of retinal degenerative diseases, such as retinitis pigmentosa, Leber's congenital Amaurosis, Syndromic retinal degenerations, age-related macular degeneration and Usher Syndrome, and hearing loss associated with Usher Syndrome are described herein.

  本文描述了用于治疗视网膜退行性疾病（如视网膜色素变性症、勒伯先天性失明、综合性视网膜退行、老年性黄斑变性和阿什尔综合征）以及与阿什尔综合征相关的听力损失的化合物、组合物和方法。
• US9227976B2
  申请人：——

  公开号：US9227976B2

  公开（公告）日：2016-01-05
• US9371332B2
  申请人：——

  公开号：US9371332B2

  公开（公告）日：2016-06-21
• US9783545B2
  申请人：——

  公开号：US9783545B2

  公开（公告）日：2017-10-10
• [EN] PYRAZOLOPYRIDAZINES AND METHODS FOR TREATING RETINAL-DEGENERATIVE DISEASES AND HEARING LOSS ASSOCIATED WITH USHER SYNDROME<br/>[FR] PYRAZOLOPYRIDAZINES ET MÉTHODES DE TRAITEMENT DE MALADIES DÉGÉNÉRATIVES DE LA RÉTINE ET DE LA PERTE D'AUDITION ASSOCIÉE AU SYNDROME D'USHER
  申请人：USHER III INITIATIVE INC

  公开号：WO2014066836A1

  公开（公告）日：2014-05-01

  Compounds, compositions and methods for the treatment of retinal degenerative diseases, such as retinitis pigmentosa, Leber's congenital Amaurosis, Syndromic retinal degenerations, age-related macular degeneration and Usher Syndrome, and hearing loss associated with Usher Syndrome are described herein. Usher Syndrome, a rare genetic disorder and a leading cause of deafness and blindness, is associated with a mutation in any one of ten genes.