5-Hexyl-1-(3-methylbutyl)triazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-Hexyl-1-(3-methylbutyl)triazole
• 英文别名: 5-hexyl-1-(3-methylbutyl)triazole
• 化学式: C₁₃H₂₅N₃
• 分子量: 223.36
• InChiKey: ADQFGAIBHCTORR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  30.7
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
  申请人：AILERON THERAPEUTICS, INC.

  公开号：US10227380B2

  公开（公告）日：2019-03-12

  Provided herein are peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.

  本文提供了拟肽大环和使用这种大环治疗疾病的方法。
• Peptidomimetic macrocycles and use thereof in regulating HIF1alpha
  申请人：AILERON THERAPEUTICS, INC.

  公开号：US10246491B2

  公开（公告）日：2019-04-02

  The present invention provides peptidomimetic macrocycles capable of regulating HIF1α and methods of using such macrocycles for the treatment of diseases.

  本发明提供了能够调节 HIF1α 的拟肽大环以及使用这种大环治疗疾病的方法。
• Peptidomimetic macrocycles and formulations thereof
  申请人：AILERON THERAPEUTICS, INC.

  公开号：US10905739B2

  公开（公告）日：2021-02-02

  Aqueous pharmaceutical formulations, for parenteral administration, comprising peptidomimetic macrocycle or a pharmaceutically acceptable salt thereof wherein the peptidomimetic macrocycle binds to MDM2 and/or MDMX proteins are disclosed. Also disclosed are methods of treating diseases and disorders using the aqueous pharmaceutical formulations disclosed herein.

  本发明公开了包含拟肽大环或其药学上可接受的盐的用于肠外给药的水性药物制剂，其中的拟肽大环与MDM2和/或MDMX蛋白结合。还公开了使用本文公开的水性药物制剂治疗疾病和失调的方法。
• STAPLED INTRACELLULAR-TARGETING ANTIMICROBIAL PEPTIDES TO TREAT INFECTION
  申请人：Dana-Farber Cancer Institute, Inc.

  公开号：US20170247423A1

  公开（公告）日：2017-08-31

  Structurally stabilized, e.g., stapled, peptides with the ability to translocate through microbial cell membranes to the interior of microbial cells and exert a biological activity there are provided, as are methods of designing, making and using such peptides.
• BIOLOGICALLY ACTIVE PEPTIDOMIMETIC MACROCYCLES
  申请人：Aileron Therapeutics, Inc.

  公开号：US20170298099A1

  公开（公告）日：2017-10-19

  The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.