3-Methyl-1-[5-methyl-3-(trifluoromethyl)pyrazol-1-yl]butan-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-Methyl-1-[5-methyl-3-(trifluoromethyl)pyrazol-1-yl]butan-2-one
• 英文别名: 3-methyl-1-[5-methyl-3-(trifluoromethyl)pyrazol-1-yl]butan-2-one
• 化学式: C₁₀H₁₃F₃N₂O
• 分子量: 234.22
• InChiKey: NKNHWVRGGOFJCS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  34.9
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• 5-5 fused rings as C5a inhibitors
  申请人：CHEMOCENTRYX, INC.

  公开号：US10683294B2

  公开（公告）日：2020-06-16

  The present disclosure provides, inter alia, Compounds of Formula (I) or pharmaceutically acceptable salts thereof that are modulators of the C5a receptor. Also provided are pharmaceutical compositions and methods of use including the treatment of diseases or disorders involving pathologic activation from C5a and non-pharmaceutical applications.

  本公开特别提供了式 (I) 化合物 或其药学上可接受的盐，它们是 C5a 受体的调节剂。此外，还提供了药物组合物和使用方法，包括治疗涉及 C5a 病理激活的疾病或失调以及非药物应用。
• 5-5 FUSED RINGS AS C5a INHIBITORS
  申请人：CHEMOCENTRYX, INC.

  公开号：US20210009594A1

  公开（公告）日：2021-01-14

  The present disclosure provides, inter alia, Compounds of Formula (I) or pharmaceutically acceptable salts thereof that are modulators of the C5a receptor. Also provided are pharmaceutical compositions and methods of use including the treatment of diseases or disorders involving pathologic activation from C5a and non-pharmaceutical applications.