2-(5-Ethyl-1,3-thiazol-2-yl)propan-2-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(5-Ethyl-1,3-thiazol-2-yl)propan-2-ol
• 英文别名: 2-(5-ethyl-1,3-thiazol-2-yl)propan-2-ol
• 化学式: C₈H₁₃NOS
• 分子量: 171.26
• InChiKey: RLWJVAIWWILGET-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  61.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] TETRAHYDRONAPHTHYRIDINE DERIVATIVES AS mGluR2-NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS, AND THEIR USE<br/>[FR] DERIVES DE TETRAHYDRONAPHTYRIDINE EN TANT QUE MODULATEURS ALLOSTERIQUES NEGATIFS DE MGLUR2, COMPOSITIONS ET UTILISATION DE CEUX-CI
  申请人：MERCK SHARP & DOHME

  公开号：WO2016032921A1

  公开（公告）日：2016-03-03

  The present invention provides quinoline carboxamide and quinoline carbonitrile compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, L, X1, X2, and X3, are as defined herein. The compounds of the invention, and pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising them, are useful as non-competitive mGluR2 antagonists, or mGluR2 negative allosteric modulators (NAMs), and may be useful in methods of treating a person in need thereof for diseases or disorders in which the mGluR2-NAM receptor plays a causative role, such as Alzheimer's disease, cognitive impairment, schizophrenia and other mood disorders, pain disorders and sleep disorders.