5-Butan-2-yl-1,2-thiazol-3-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-Butan-2-yl-1,2-thiazol-3-one
• 英文别名: 5-butan-2-yl-1,2-thiazol-3-one
• 化学式: C₇H₁₁NOS
• 分子量: 157.24
• InChiKey: DAJBESJFILGAKK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] HISTONE DEMETHYLASE INHIBITORS FOR TREATING CANCERS<br/>[FR] INHIBITEURS D'HISTONE DÉMÉTHYLASE POUR LE TRAITEMENT DE CANCERS
  申请人：UNIV TEXAS

  公开号：WO2020257733A1

  公开（公告）日：2020-12-24

  The present disclosure provides a new series of 8-hydroxyquinoline derivatives/analogs that are potent KDM4 inhibitors with high activity and selectivity against KDM4 enzymes. Also disclosed are the pharmaceutical compositions comprising such 8-hydroxyquinoline-based potent KDM4 inhibitors, or a pharmaceutically acceptable salt thereof, and method of use thereof, for treating cancer and neoplastic diseases and the like.

  本公开提供了一系列新的8-羟基喹啉衍生物/类似物，它们是有效的KDM4抑制剂，对KDM4酶具有高活性和选择性。还公开了包含这些基于8-羟基喹啉的有效KDM4抑制剂或其药用盐的药物组合物，以及使用方法，用于治疗癌症、肿瘤性疾病等。
• Bromodomain inhibitors
  申请人：CELGENE QUANTICEL RESEARCH, INC.

  公开号：US10941160B2

  公开（公告）日：2021-03-09

  The present invention relates to substituted heterocyclic derivative compounds, compositions comprising said compounds, and the use of said compounds and compositions for epigenetic regulation by inhibition of bromodomain-mediated recognition of acetyl lysine regions of proteins, such as histones. Said compositions and methods are useful for the treatment of cancer and neoplastic disease.

  本发明涉及取代的杂环衍生物化合物、包含所述化合物的组合物，以及所述化合物和组合物通过抑制溴域介导的对蛋白质（如组蛋白）乙酰赖氨酸区的识别来进行表观遗传调控的用途。所述组合物和方法可用于治疗癌症和肿瘤性疾病。
• BROMODOMAIN INHIBITORS
  申请人：CELGENE QUANTICEL RESEARCH, INC.

  公开号：US20200148703A1

  公开（公告）日：2020-05-14

  The present invention relates to substituted heterocyclic derivative compounds, compositions comprising said compounds, and the use of said compounds and compositions for epigenetic regulation by inhibition of bromodomain-mediated recognition of acetyl lysine regions of proteins, such as histones. Said compositions and methods are useful for the treatment of cancer and neoplastic disease.
• US9771329B2
  申请人：——

  公开号：US9771329B2

  公开（公告）日：2017-09-26