2-[2-(acetylamino)-4-(diallylamino)-5-methoxyphenyl]-5-amino-7-bromo-4-chloro-2H-benzotriazole | 468062-50-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-[2-(acetylamino)-4-(diallylamino)-5-methoxyphenyl]-5-amino-7-bromo-4-chloro-2H-benzotriazole
• 英文别名: N-[2-(5-amino-7-bromo-4-chlorobenzotriazol-2-yl)-5-[bis(prop-2-enyl)amino]-4-methoxyphenyl]acetamide
• CAS: 468062-50-2
• 化学式: C₂₁H₂₂BrClN₆O₂
• 分子量: 505.802
• InChiKey: ZLGPTNBRKWCBIG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  98.3
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-[2-(acetylamino)-4-(diallylamino)-5-methoxyphenyl]-6-amino-4-bromo-2H-benzotriazole 在 sodium hypochlorite 作用下， 以 二氯甲烷 为溶剂， 反应 0.08h， 以75%的产率得到2-[2-(acetylamino)-4-(diallylamino)-5-methoxyphenyl]-5-amino-7-bromo-4-chloro-2H-benzotriazole
  参考文献：
  名称：

  Watanabe, Tetsushi; Shiozawa, Tatsushi; Takahashi, Yoshifumi, Mutagenesis, 2002, vol. 17, # 4, p. 293 - 299

  摘要：

  DOI：

文献信息

• METHODS FOR EXTENDING LIFESPAN AND METHODS OF SCREENING KNOWN PHARMACOLOGICAL AGENTS FOR NEW USES
  申请人：Longevica Therapeutics Inc.

  公开号：US20180256617A1

  公开（公告）日：2018-09-13

  The present disclosure relates to methods of extending the lifespan of a subject or treating, suppressing, inhibiting or delaying the onset of an age-related condition or disorder, such as cancer, in a subject. The methods comprise administering to the subject an effective amount of (i) a compound that sustains pharmacological activation of xenobiotic metabolism, (ii) a cardiac glycoside, (iii) a chelator, (iv) inulin, (v) D-valine, or any combination thereof. In a further aspect, the present disclosure relates to a method of identifying clinical candidates by performing a high throughput screening in mammals of test compounds which have great structural and/or functional diversity.
• [EN] METHODS FOR EXTENDING LIFESPAN AND METHODS OF SCREENING KNOWN PHARMACOLOGICAL AGENTS FOR NEW USES<br/>[FR] PROCÉDÉS D'EXTENSION DE LA DURÉE DE VIE ET PROCÉDÉS DE CRIBLAGE D'AGENTS PHARMACOLOGIQUES POUR NOUVELLES UTILISATIONS
  申请人：LONGEVICA THERAPEUTICS INC

  公开号：WO2016168670A2

  公开（公告）日：2016-10-20

  The present disclosure relates to methods of extending the lifespan of a subject or treating, suppressing, inhibiting or delaying the onset of an age-related condition or disorder, such as cancer, in a subject. The methods comprise administering to the subject an effective amount of (i) a compound that sustains pharmacological activation of xenobiotic metabolism, (ii) a cardiac glycoside, (iii) a chelator, (iv) inulin, (v) D-valine, or any combination thereof. In a further aspect, the present disclosure relates to a method of identifying clinical candidates by performing a high throughput screening in mammals of test compounds which have great structural and/or functional diversity.