[5-(5-Chlorothiophen-2-yl)-1,3-oxazol-4-yl] 2-(6-azidopyridin-3-yl)butanoate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: [5-(5-Chlorothiophen-2-yl)-1,3-oxazol-4-yl] 2-(6-azidopyridin-3-yl)butanoate
• 英文别名: [5-(5-chlorothiophen-2-yl)-1,3-oxazol-4-yl] 2-(6-azidopyridin-3-yl)butanoate
• 化学式: C16H12ClN5O3S
• 分子量: 389.8
• InChiKey: GAXOJLKEYZRNOG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  108
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• IMIDAZOLE, THIAZOLE AND OXAZOLE DERIVATIVES AND THEIR USE FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT AND/OR PREVENTION OF POLLAKIURIA OR URINARY INCONTINENCE
  申请人：Tanabe Seiyaku Co., Ltd.

  公开号：EP1432690A2

  公开（公告）日：2004-06-30
• [EN] LARGE CONDUCTANCE CALCIUM-ACTIVATED K CHANNEL OPENER<br/>[FR] SUBSTANCE D'OUVERTURE DU CANAL K ACTIVEE PAR LE CALCIUM A GRANDE CONDUCTANCE
  申请人：TANABE SEIYAKU CO

  公开号：WO2002083111A2

  公开（公告）日：2002-10-24

  A large conductance calcium-activated K channel opener comprising as an active ingredient a nitrogen-containing 5-membered heterocyclic compound represented by the following formula (I): wherein X represents N-R4, O or S, R1 and R 2 each independently represent hydrogen, halogen carboxyl, amino, lower alkyl, lower alkoxycarbonyl, lower alkenyl, cyclo-lower alkyl, carbamoyl, aryl, heterocyclic or heterocyclic-substituted carbonyl group, R3 represents aryl, heterocyclic or lower alkyl group, and R4 represents hydrogen or lower alkyl group, or a pharmaceutically acceptable salt thereof and its use for the preparation of a medicament for the phophylaxis and/or treatment of pollakiuria or urinary incontinence.