1-Methyl-4-(3-phenoxypropyl)piperazine | 116871-22-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-Methyl-4-(3-phenoxypropyl)piperazine
• CAS: 116871-22-8
• 化学式: C₁₄H₂₂N₂O
• 分子量: 234.341
• InChiKey: GQQSQIJENQRBBW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.571
• 拓扑面积：
  15.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-甲基哌嗪 、 3-苯氧基溴丙烷 以 四氢呋喃 为溶剂， 反应 48.0h， 以78%的产率得到1-Methyl-4-(3-phenoxypropyl)piperazine
  参考文献：
  名称：

  新型烷基哌嗪作为潜在多巴胺拮抗剂的合成与评价。

  摘要：

  在分离的兔耳动脉制剂中，几种烷基哌嗪（已知的三环抗精神病药的单环亚片段）被评估为多巴胺拮抗剂。制备和评估的化合物具有一般结构Ar-X-（CH2）nY，其中X = C，O和N，n = 1-3，Y大部分是4-甲基哌嗪。X-NH，n = 3，X =（Z）-CH-CH，n = 2，侧链上有一个吸电子基团的那些化合物，其多巴胺拮抗剂活性与氯氮平相当。结论是，在本研究中使用的受体制剂中，作为多巴胺拮抗剂的最佳活性，吩噻嗪样药物的整个三环结构（或至少大于一个单环系统）是必需的。

  DOI：

  10.1021/jm00138a007

文献信息

• Polyene macrolide derivative
  申请人：Shionogi & Co., Ltd.

  公开号：US10696707B2

  公开（公告）日：2020-06-30

  The present invention is the following Amphotericin B derivative: wherein each symbol is defined in description. The compound of the present invention has 16th position (X) is urea structure, cyclic structure, hydroxyalkyl or substituted monoalkylcarbamoyl. The compound of the present invention has antifungal activity.

  本发明是以下两性霉素 B 衍生物： 其中各符号在说明中定义。本发明化合物的第 16 位（X）是脲结构、环状结构、羟烷基或取代的单烷基氨基甲酰基。本发明化合物具有抗真菌活性。
• GLENNON, R. A.;SALLEY, J. J. ,, JR;STEINSLAND, O. S.;NELSON, S., J. MED. CHEM., 1981, 24, N 6, 678-683
  作者：GLENNON, R. A.、SALLEY, J. J. ,, JR、STEINSLAND, O. S.、NELSON, S.

  DOI：——

  日期：——
• POLYENE MACROLIDE DERIVATIVE
  申请人：Shionogi & Co., Ltd.

  公开号：US20170190729A1

  公开（公告）日：2017-07-06

  The present invention is the following Amphotericin B derivative: wherein each symbol is defined in description. The compound of the present invention has 16th position (X) is urea structure, cyclic structure, hydroxyalkyl or substituted monoalkylcarbamoyl. The compound of the present invention has antifungal activity.
• [EN] CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME<br/>[FR] LIGANDS DE CÉRÉBLON ET COMPOSÉS BIFONCTIONNELS LES CONTENANT
  申请人：ARVINAS OPERATIONS INC

  公开号：WO2019199816A1

  公开（公告）日：2019-10-17

  The description relates to cereblon E3 ligase binding compounds, including bifunctional compounds comprising the same, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present disclosure. In particular, the description provides compounds, which contain on one end a ligand which binds to the cereblon E3 ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. Compounds can be synthesized that exhibit a broad range of pharmacological activities consistent with the degradation/inhibition of targeted polypeptides of nearly any type.
• Synthesis and evaluation of novel alkylpiperazines as potential dopamine antagonists
  作者：Richard A. Glennon、John J. Salley、Odd S. Steinsland、Sharon Nelson

  DOI：10.1021/jm00138a007

  日期：1981.6

  Several alkylpiperazines, monocyclic subfragments of known tricyclic neuroleptic agents, were evaluated as dopamine antagonists in the isolated rabbit ear artery preparation. Compound prepared and evaluated are of the general structure Ar-X-(CH2)n-Y, where X = C, O, and N, n = 1-3, and Y, for the most part, was 4-methylpiperazine. Those compounds where X - NH, n = 3, and X = (Z)-CH - CH, n = 2, with

  在分离的兔耳动脉制剂中，几种烷基哌嗪（已知的三环抗精神病药的单环亚片段）被评估为多巴胺拮抗剂。制备和评估的化合物具有一般结构Ar-X-（CH2）nY，其中X = C，O和N，n = 1-3，Y大部分是4-甲基哌嗪。X-NH，n = 3，X =（Z）-CH-CH，n = 2，侧链上有一个吸电子基团的那些化合物，其多巴胺拮抗剂活性与氯氮平相当。结论是，在本研究中使用的受体制剂中，作为多巴胺拮抗剂的最佳活性，吩噻嗪样药物的整个三环结构（或至少大于一个单环系统）是必需的。