2,4-diisopropoxyphenylacetyl chloride | 238736-99-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2,4-diisopropoxyphenylacetyl chloride
• 英文别名: 2-[2,4-Di(propan-2-yloxy)phenyl]acetyl chloride
• CAS: 238736-99-7
• 化学式: C₁₄H₁₉ClO₃
• 分子量: 270.756
• InChiKey: ZLVRCUKTYOWBPP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,4-diisopropoxyphenylacetyl chloride 在 仲丁基锂 、 sodium hydride 、 zinc(II) chloride 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 5.0h， 生成 2-(2,4-Diisopropoxy-phenyl)-N,N-diethyl-3-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-oxo-propionamide
  参考文献：
  名称：

  Directed Metalation Linked to Transition Metal Catalyzed Cascade Reactions: Two Total Syntheses of Plicadin, the Alleged Coumestan fromPsoralea plicata

  摘要：

  The oxygen-rich heterocyclic compound 1-which was proposed to be the structure of plicadin, the alleged naturally occurring coumestan from the herb Psoralea plicata-was synthesized by the rational combinations of directed ortho and remote metalation reactions with cascades of Negishi, Sonogashira, Castro-Stephens, and carbamoyl Baker-Venkataraman reactions.

  DOI：

  10.1002/(sici)1521-3773(19990517)38:10<1435::aid-anie1435>3.0.co;2-b
• 作为产物：
  描述：

  methyl 2,4-diisopropoxyphenylacetate 在 sodium hydroxide 、 草酰氯 作用下， 以 甲醇 为溶剂， 反应 3.5h， 生成 2,4-diisopropoxyphenylacetyl chloride
  参考文献：
  名称：

  Kwakhurin, a Unique Isoflavone with Rejuvenating Activity from “Kwao Keur”: Further Characterization by 2D-NMR Spectrometry and Synthesis of Triisopropylkwakhurin

  摘要：

  DOI：

  10.3987/com-04-10060

文献信息

• Directed Metalation Linked to Transition Metal Catalyzed Cascade Reactions: Two Total Syntheses of Plicadin, the Alleged Coumestan fromPsoralea plicata
  作者：Brian A. Chauder、Alexey V. Kalinin、Nicholas J. Taylor、Victor Snieckus

  DOI：10.1002/(sici)1521-3773(19990517)38:10<1435::aid-anie1435>3.0.co;2-b

  日期：1999.5.17

  The oxygen-rich heterocyclic compound 1-which was proposed to be the structure of plicadin, the alleged naturally occurring coumestan from the herb Psoralea plicata-was synthesized by the rational combinations of directed ortho and remote metalation reactions with cascades of Negishi, Sonogashira, Castro-Stephens, and carbamoyl Baker-Venkataraman reactions.
• Kwakhurin, a Unique Isoflavone with Rejuvenating Activity from “Kwao Keur”: Further Characterization by 2D-NMR Spectrometry and Synthesis of Triisopropylkwakhurin
  作者：Toshiko Watanabe、Misako Iwasaki、Tsutomu Ishikawa、Sunee Chansakaow、Yoshihiro Higuchi、Satoshi Tahara

  DOI：10.3987/com-04-10060

  日期：——