3-methyl-2-(piperidin-1-yl)-3-vinylindolenine | 1632371-85-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-methyl-2-(piperidin-1-yl)-3-vinylindolenine
• 英文别名: 3-Ethenyl-3-methyl-2-piperidin-1-ylindole；3-ethenyl-3-methyl-2-piperidin-1-ylindole
• CAS: 1632371-85-7
• 化学式: C₁₆H₂₀N₂
• 分子量: 240.348
• InChiKey: KAVQJFAJMUAPLH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  15.6
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (E)-N-(2-(4-hydroxybut-2-en-2-yl)phenyl)formamide 在 吡啶 、 三(2-呋喃基)膦 、 三乙胺 、 bis(dibenzylideneacetone)-palladium⁽⁰⁾ 、 三氯氧磷 作用下， 以 四氢呋喃 、 二氯甲烷 、 甲苯 为溶剂， 反应 4.5h， 生成 3-methyl-2-(piperidin-1-yl)-3-vinylindolenine
  参考文献：
  名称：

  Synthesis of 3,3-Disubstituted 2-Aminoindolenines by Palladium-Catalyzed Allylic Amidination with Isocyanide

  摘要：

  Synthesis of 3,3-disubstituted 2-aminoindolenines was achieved by palladium-catalyzed allylic amidination with an isocyanide. It was found that isocyanides are effective building blocks in palladium-catalyzed allylic functionalizations, analogous to carbon monoxide. This approach enables the direct construction of the indolenine ring along with the formation of a quaternary carbon and the introduction of an amino substituent in one step under mild conditions.

  DOI：

  10.1055/s-0033-1341241

文献信息

• Synthesis of 3,3-Disubstituted 2-Aminoindolenines by Palladium-Catalyzed Allylic Amidination with Isocyanide
  作者：Yoshiji Takemoto、Takeshi Nanjo、Chihiro Tsukano

  DOI：10.1055/s-0033-1341241

  日期：——

  Synthesis of 3,3-disubstituted 2-aminoindolenines was achieved by palladium-catalyzed allylic amidination with an isocyanide. It was found that isocyanides are effective building blocks in palladium-catalyzed allylic functionalizations, analogous to carbon monoxide. This approach enables the direct construction of the indolenine ring along with the formation of a quaternary carbon and the introduction of an amino substituent in one step under mild conditions.