tert-butyl N-(1-azido-2-benzyl-3-phenylpropan-2-yl)carbamate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: tert-butyl N-(1-azido-2-benzyl-3-phenylpropan-2-yl)carbamate
• 化学式: C21H26N4O2
• 分子量: 366.5
• InChiKey: XXVDIBYDFSNPAR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  27
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  52.7
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• (INDAZOL-5-YL)-PYRAZINES AND (1,3-DIHYDRO-INDOL-2-ONE)-PYRAZINES FOR TREATING RHO KINASE-MEDIATED DISEASES AND CONDITIONS
  申请人：Hellberg R. Mark

  公开号：US20070149548A1

  公开（公告）日：2007-06-28

  Methods for using (indazol-5-yl)-pyrazines and (1,3-dihydro-indol-2-one)-pyrazines are disclosed herein to treat rho kinase-mediated diseases or rho kinase-mediated conditions, including controlling intraocular pressure and treating glaucoma, are disclosed. Ophthalmic pharmaceutical compositions useful in the treatment of eye diseases such as glaucoma, and additionally useful for controlling intraocular pressure, the compositions comprising an effective amount of (indazol-5-yl)-pyrazines and (1,3-dihydro-indol-2-one)-pyrazines, are disclosed herein.

  本文披露了使用（indazol-5-yl）-pyrazines和（1,3-dihydro-indol-2-one）-pyrazines治疗rho激酶介导的疾病或rho激酶介导的病状的方法，包括控制眼压和治疗青光眼。本文还披露了用于治疗眼疾如青光眼以及控制眼压的眼科制药组合物，其中包括有效量的（indazol-5-yl）-pyrazines和（1,3-dihydro-indol-2-one）-pyrazines。
• (INDAZOL-5-YL)-PYRAZINES AND (1,3-DIHYDRO-INDOL-2-ONE)- PYRAZINES FOR TREATING RHO KINASE-MEDIATED DISEASES AND CONDITIONS
  申请人：Alcon Research, Ltd.

  公开号：EP1962853A1

  公开（公告）日：2008-09-03
• US7655662B2
  申请人：——

  公开号：US7655662B2

  公开（公告）日：2010-02-02
• [EN] (INDAZOL-5-YL)-PYRAZINES AND (1,3-DIHYDRO-INDOL-2-ONE)- PYRAZINES FOR TREATING RHO KINASE-MEDIATED DISEASES AND CONDITIONS<br/>[FR] (INDAZOL-5-YL)-PYRAZINES ET (1,3-DIHYDRO-INDOL-2-UN)- PYRAZINES POUR LE TRAITEMENT DE MALADIES ET DE CONDITIONS A MEDIATION DE RHO KINASE
  申请人：ALCON MFG LTD

  公开号：WO2007076360A1

  公开（公告）日：2007-07-05

  [EN] Methods for using (indazol-5-yl)-pyrazines and (1,3-dihydro-indol-2-one)-pyrazines are disclosed herein to treat rho kinase-mediated diseases or rho kinase-mediated conditions, including controlling intraocular pressure and treating glaucoma, are disclosed. Ophthalmic pharmaceutical compositions useful in the treatment of eye diseases such as glaucoma, and additionally useful for controlling intraocular pressure, the compositions comprising an effective amount of (indazol-5-yl)-pyrazines and (1,3-dihydro-indol-2-one)-pyrazines, are disclosed herein.
  [FR] La présente invention concerne des procédés d'utilisation d'(indazol-5-yl)-pyrazines et de (1,3-dihydro-indol-2-one)-pyrazines pour traiter des maladies ou des conditions à médiation de rho-kinase, y compris le contrôle de pression intra-oculaire et le traitement du glaucome. Sont présentées des compositions pharmaceutiques ophthalmiques utiles dans le traitement de maladies oculaires telles que le glaucome et utiles par ailleurs pour contrôler la pression intraoculaire, ces compositions comprenant une quantité effective d'(indazol-5-yl)-pyrazines et d'(1,3-dihydro-indol-2-un)-pyrazines.