2-[4-(Hydroxymethyl)-1,3-thiazol-5-yl]ethanol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-[4-(Hydroxymethyl)-1,3-thiazol-5-yl]ethanol
• 英文别名: 2-[4-(hydroxymethyl)-1,3-thiazol-5-yl]ethanol
• 化学式: C₆H₉NO₂S
• 分子量: 159.21
• InChiKey: KSHOEJDAHWLEMP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  81.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF SUMO ACTIVATING ENZYME
  申请人：Millennium Pharmaceuticals, Inc.

  公开号：US20170216290A1

  公开（公告）日：2017-08-03

  Disclosed are chemical entities which are compounds of formula (I): or pharmaceutically acceptable salts thereof; wherein Y, R a , R a′ , R b , R c , X 1 , X 2 , X 3 , R d , Z 1 , and Z 2 have the values described herein and stereochemical configurations depicted at asterisked positions indicate absolute stereochemistry. Chemical entities according to the disclosure can be useful as inhibitors of Sumo Activating Enzyme (SAE). Further provided are pharmaceutical compositions comprising a compound of the disclosure and methods of using the compositions in the treatment of proliferative, inflammatory, cardiovascular, and neurodegenerative diseases or disorders.
• US9683003B2
  申请人：——

  公开号：US9683003B2

  公开（公告）日：2017-06-20