2-acetamido-2-ethyl-1,3-propanediol | 39116-23-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-acetamido-2-ethyl-1,3-propanediol
• 英文别名: N-[1-hydroxy-2-(hydroxymethyl)butan-2-yl]acetamide
• CAS: 39116-23-9
• 化学式: C₇H₁₅NO₃
• 分子量: 161.201
• InChiKey: HVXXNAOQUJQTTR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  69.6
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-acetamido-2-ethyl-1,3-propanediol 在 盐酸 、 水 作用下， 以 甲醇 为溶剂， 生成 2-氨基-2-乙基-1,3-丙二醇
  参考文献：
  名称：

  Pd-Containing Organopolyoxometalates Derived from Dawson Polyoxometalate [P₂W₁₅V₃O₆₂]^9–: Lewis Acidity and Dual Site Catalysis

  摘要：

  Grafting of a palladium complex to the Dawson vanadotungstate polyanion [P2W15V3O62](9-) via an organic ligand generates a large family of pincer-type hybrid polyoxometalates. The palladium-POM derivatives have dual catalytic properties. Unlike their parent inorganic polyanions, they catalyze allylations while retaining their oxidant character, which leads to single-pot dual site catalysis. This opens a new route for multicatalytic reactions.

  DOI：

  10.1021/ol501644c
• 作为产物：
  描述：

  2-乙酰氨基-2-乙基丙二酸二乙酯 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 生成 2-acetamido-2-ethyl-1,3-propanediol
  参考文献：
  名称：

  Pd-Containing Organopolyoxometalates Derived from Dawson Polyoxometalate [P₂W₁₅V₃O₆₂]^9–: Lewis Acidity and Dual Site Catalysis

  摘要：

  Grafting of a palladium complex to the Dawson vanadotungstate polyanion [P2W15V3O62](9-) via an organic ligand generates a large family of pincer-type hybrid polyoxometalates. The palladium-POM derivatives have dual catalytic properties. Unlike their parent inorganic polyanions, they catalyze allylations while retaining their oxidant character, which leads to single-pot dual site catalysis. This opens a new route for multicatalytic reactions.

  DOI：

  10.1021/ol501644c

文献信息

• Insertion of Amides into a Polyoxometalate
  作者：Joaquim Li、Inga Huth、Lise-Marie Chamoreau、Bernold Hasenknopf、Emmanuel Lacôte、Serge Thorimbert、Max Malacria

  DOI：10.1002/anie.200805964

  日期：2009.3.2

  POM alert: The incorporation of an amide oxygen atom into the framework of the Dawson‐type polyoxometalate (POM) cluster [P2V3W15O62]9− (see picture) allows the communication of electronic effects between the organic and the inorganic parts of the molecule, including fine‐tuning of the redox properties of the entire hybrid POM by the organic components, and transmission of the POM's electron‐attracting

  POM警报：在Dawson型多金属氧酸盐（POM）簇[P 2 V 3 W 15 O 62 ] 9−的框架中掺入酰胺氧原子，可以在有机物和有机物之间传递电子效应。分子的无机部分，包括通过有机成分对整个杂化POM的氧化还原特性进行微调，以及将POM的电子吸引特性传递至有机部分。
• CROSSLINKED POLYMER NANO-ASSEMBLIES AND USES THEREOF
  申请人：University of Massachusetts

  公开号：US20170216450A1

  公开（公告）日：2017-08-03

  The invention provides a novel system of nano-assemblies and related method for delivery of therapeutic, diagnostic or imaging agent to biological sites. The compositions and methods of the invention enable the syntheses of novel polymeric nano-assemblies (nanoparticles) under non-emulsion conditions with the incorporation of hydrophobic guest molecules. The versatilities and advantages of the polymer nanoparticles of the invention include: (i) the guest molecules (e.g., drug molecules) can be readily incorporated non-covalently within the nanoparticles; (ii) the surface of the nanoparticles are functionalizable; (iii) the non-covalently encapsulated guest molecule (payload) can be released in response to a biologically relevant stimulus at the target site; (iv) the payload is held by the polymeric nanoparticle before being internalized in cells and can be released within the cellular interiors; (v) encapsulating lipophilic small molecules within its crosslinked interiors and binding proteins on its surface through electrostatic interactions; (vi) facile synthetic methods for ligand functionalization that can be utilized to decorate nanogels with cell targeting ligands that facilitate receptor-dependent cellular uptake, and (vii) the payload release kinetics is tunable and controllable.
• US9592302B2
  申请人：——

  公开号：US9592302B2

  公开（公告）日：2017-03-14
• Pd-Containing Organopolyoxometalates Derived from Dawson Polyoxometalate [P₂W₁₅V₃O₆₂]^9–: Lewis Acidity and Dual Site Catalysis
  作者：Benoît Riflade、David Lachkar、Julie Oble、Joaquim Li、Serge Thorimbert、Bernold Hasenknopf、Emmanuel Lacôte

  DOI：10.1021/ol501644c

  日期：2014.8.1

  Grafting of a palladium complex to the Dawson vanadotungstate polyanion [P2W15V3O62](9-) via an organic ligand generates a large family of pincer-type hybrid polyoxometalates. The palladium-POM derivatives have dual catalytic properties. Unlike their parent inorganic polyanions, they catalyze allylations while retaining their oxidant character, which leads to single-pot dual site catalysis. This opens a new route for multicatalytic reactions.