fumaric acid bis-(2-methoxy-ethyl ester) | 10578-13-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: fumaric acid bis-(2-methoxy-ethyl ester)
• 英文别名: Fumarsaeure-bis-(2-methoxy-aethylester)；Fumaric acid, di(2-methoxyethyl) ester；bis(2-methoxyethyl) (E)-but-2-enedioate
• CAS: 10578-13-9
• 化学式: C₁₀H₁₆O₆
• mdl: MFCD18431883
• 分子量: 232.233
• InChiKey: INJVHPRSHKTTBD-ONEGZZNKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  16
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-苯基脲唑 、 fumaric acid bis-(2-methoxy-ethyl ester) 在 三乙烯二胺 、 四丁基溴化铵 作用下， 以 neat (no solvent) 为溶剂， 反应 2.5h， 以80%的产率得到(Z)-2-methoxyethyl 2-(2,5-dioxo-1-phenylimidazolidin-4-ylidene)acetate
  参考文献：
  名称：

  乙内酰脲从4-苯基脲基的迈克尔加成到富马酸酯的过程中，意外生成了乙内酰脲的5-亚烷基衍生物

  摘要：

  本文描述了4-苯基脲和富马酸酯之间的意外反应，该反应导致乙内酰脲的5-亚烷基衍生物的形成。反应在无溶剂条件下，在四丁基溴化铵（TBAB）和1,4-二氮杂双环[2,2,2]辛烷（DABCO）的存在下于70°C进行。

  DOI：

  10.1016/j.tet.2016.02.024

文献信息

• Heat-curable silicone compositions comprising fumarate cure-control additive and use thereof
  申请人：DOW CORNING CORPORATION

  公开号：EP0297746A2

  公开（公告）日：1989-01-04

  Compositions which cure by a platinum-catalyzed reaction between silicon-bonded hydrogen atoms and silicon-­bonded, aliphatically unsaturated hydrocarbon radicals have improved pot-life and cure-rate characteristics when a catalyst-inhibiting amount of a diorgano fumarate compound is added to the composition. Solventless coating compositions containing a dialkyl fumarate, a methylhydrogenpolysiloxane and a methylpolysiloxane bearing hexenyl radicals are particularly useful as adhesive-release coatings for acrylic-based pressure sensitive adhesives, applied in-line.

  通过硅键氢原子和硅键脂肪族不饱和烃基之间的铂催化反应而固化的组合物，如果在组合物中加入一定量的富马酸二烷基酯化合物的催化剂抑制剂，其固化寿命和固化速率特性都会得到改善。含有富马酸二烷基酯、含己烯基的甲基氢聚硅氧烷和甲基聚硅氧烷的无溶剂涂料组合物，特别适用于丙烯酸基压敏胶的粘合剂脱模涂料。
• Coating varnish composition and antifouling coating composition
  申请人：Hitachi Chemical Co., Ltd.

  公开号：EP0711813A2

  公开（公告）日：1996-05-15

  A coating varnish composition comprising a biodegradable polymer (A) comprising one or more kinds of constituent units (b) represented by the general formula (I), (II) or (III) and one or more other kinds of constituent units (a) capable of imparting bio-degradability: wherein in the formula (I), R¹ and R are independently a hydrogen atom, a chlorine atom, a bromine atom, a methyl group, an ethyl group or a phenyl group; in the formula (II), R³ and R⁴ are independently a hydrogen atom, a chlorine atom, a bromine atom, or a substituted or unsubstituted methyl or ethyl group; in the formula (III), R⁵ and R⁶ are independently a hydrogen atom, a methyl group or an ethyl group, and R⁷ is a straight, branched or cyclic alkyl group, an aryl group, a heterocyclic group or an aralkyl group, which may have one or more substituents.

  一种涂料清漆组合物，包含一种可生物降解聚合物 (A)，该聚合物包含一种或多种由通式 (I)、(II) 或 (III) 表示的组成单元 (b) 和一种或多种可赋予生物降解性的其他组成单元 (a)： 其中，在式 (I) 中，R¹ 和 R 独立地为氢原子、氯原子、溴原子、甲基、乙基或苯基；在式 (II) 中，R³ 和 R⁴ 独立地为氢原子、氯原子、溴原子或取代或未取代的甲基或乙基；在式 (III) 中，R⁵ 和 R⁶ 独立地是氢原子、甲基或乙基，R⁷ 是直链、支链或环状烷基、芳基、杂环基或芳烷基，它们可以有一个或多个取代基。
• Coating composition
  申请人：NOF CORPORATION

  公开号：EP0802243A2

  公开（公告）日：1997-10-22

  A coating composition comprising a rosin compound, a polymer containing organosilyl ester groups, and an antifoulant as essential components is disclosed. This rosin-based coating composition gives a coating film which forms no residue layer on the surface thereof over long-term immersion, is hence free from physical defects such as cracks and peeling and capable of maintaining a sufficiently high rate of film erosion and preventing the attachment of marine organisms over long, has satisfactory suitability for recoating, and has the satisfactory ability to prevent marine-organism attachment over the out-fitting period.

  本发明公开了一种涂料组合物，其主要成分包括松香化合物、含有有机硅酯基团的聚合物和防污剂。这种以松香为基础的涂层组合物所形成的涂膜在长期浸泡后不会在其表面形成残留层，因此不会出现裂缝和剥落等物理缺陷，并能保持足够高的涂膜侵蚀率和长期防止海洋生物附着，具有令人满意的重涂适用性，以及在淘汰期内具有令人满意的防止海洋生物附着的能力。
• SKIN EXTERNAL AGENTS AND DRUGS
  申请人：Kanebo Limited

  公开号：EP1249237A1

  公开（公告）日：2002-10-16

  The present invention provides an epidermal permeability barrier function-enhancing agent, an amphiregulin expression inhibitor, an epidermal hyperproliferation inhibitor, a heparin-binding epidermal growth factor-like growth factor (HB-EGF) expression inducing agent, an ameliorating agent for aged skin, an agent to be used together with retinoic acid or a derivative thereof, an agent to prevent dry skin caused by retinoic acid, and a skin external agent composition, which all comprises fumaric acid diester derivatives expressed by the following general formula (1) wherein R1 represents a C1-4 alkylene group; R2 and R3 each represents a linear or branched C1-8 alkyl group; and n is an integer of 2 to 5.

  本发明提供了一种表皮通透性屏障功能增强剂、一种表皮生长素表达抑制剂、一种表皮过度增殖抑制剂、一种肝素结合表皮生长因子样生长因子（HB-EGF）表达诱导剂、一种老化皮肤改善剂，一种与维甲酸或其衍生物一起使用的制剂，一种防止维甲酸引起皮肤干燥的制剂，以及一种皮肤外用制剂组合物，它们都包含由以下通式（1）表示的富马酸二酯衍生物 其中 R1 代表 C1-4 亚烷基；R2 和 R3 分别代表直链或支链 C1-8 烷基；n 为 2 至 5 的整数。
• ANTIFOULING COATING MATERIAL, ANTIFOULING COATING FILM, SUBMERGED STRUCTURE, AND ANTIFOULING METHOD
  申请人：BASF NOF Coatings Co., Ltd.,

  公开号：EP1277816A1

  公开（公告）日：2003-01-22

  According to this invention: excellent antifouling paint films exhibiting such a preferable film-erosion property and superior antifouling activity that can steadily be maintained for a very long period of time even from the beginning when used in sea-water and having outstanding basic paint-film properties and high water-resistance can be provided; antifouling paint by using of which such excellent antifouling paint films can be formed, which can stably be preserved for long, can be provided; structures used in or in contact with water such as sea-warter, having an antifouling paint film(s) formed by using the antifouling paint of this invention on its surface(s), by using of which such antifouling paint films which can easily prevent the attachment of marine organisms, such as barnacles and the like, to their surface(s) can be provided; and methods for preventing from fouling to prevent the attachment of marine organisms, such as barnacles and the like, to the surface(s) of the hull of ships or structures immersed in or in contact with sea-water can be provided.

  根据本发明 本发明的目的是： 提供一种优异的防污漆膜，这种漆膜具有优越的漆膜侵蚀特性和优异的防污活性，即使在海 根据本发明：可以提供优异的防污漆膜，这些漆膜具有优越的漆膜侵蚀性和优异的防污活性，即使在海水中使用，也能从一开始就稳定地保持很长一段时间，并且具有优异的漆膜基本特性和高耐水性； 防污漆，使用这种防污漆可以形成可长期稳定保持的优异防污漆膜； 在其表面使用本发明的防污漆形成防污漆膜的海船等水中使用或与水接触的构筑物，使用本发明的防污漆可提供易于防止藤壶等海洋生物附着在其表面的防污漆膜； 以及防止海洋生物（如藤壶等）附着在浸入海水或与海水接触的船体或结构表面的防污方法。