methyl 15-[(2R,3R,4R,5S,6S)-6-methyl-3,4,5-tris(phenylmethoxy)oxan-2-yl]oxypentadecanoate | 273737-71-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: methyl 15-[(2R,3R,4R,5S,6S)-6-methyl-3,4,5-tris(phenylmethoxy)oxan-2-yl]oxypentadecanoate
• CAS: 273737-71-6
• 化学式: C₄₃H₆₀O₇
• 分子量: 688.945
• InChiKey: ORHDNVKYEUTCRS-NHQOVNGNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.3
• 重原子数：
  50
• 可旋转键数：
  26
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  72.4
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  methyl 15-[(2R,3R,4R,5S,6S)-6-methyl-3,4,5-tris(phenylmethoxy)oxan-2-yl]oxypentadecanoate 在 sodium hydroxide 作用下， 反应 0.5h， 以73%的产率得到15-[(2R,3R,4R,5S,6S)-6-methyl-3,4,5-tris(phenylmethoxy)oxan-2-yl]oxypentadecanoic acid
  参考文献：
  名称：

  Synthesis and transfecting properties of a glycosylated polycationic DNA vector 1

  摘要：

  A glycosylated analogue of dialkylamidoglycylcarboxyspermine was synthesized. The physico-chemical and transfecting properties of 11 were evaluated indicating that this cationic lipid forms stable particles at low charge ratio and is efficient for gene delivery. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00683-1
• 作为产物：
  描述：

  15-羟基十五烷酸甲酯 在 甲醇 、 sodium methylate 、 四氯化锡 、 sodium hydride 、 potassium iodide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.5h， 生成 methyl 15-[(2R,3R,4R,5S,6S)-6-methyl-3,4,5-tris(phenylmethoxy)oxan-2-yl]oxypentadecanoate
  参考文献：
  名称：

  Synthesis and transfecting properties of a glycosylated polycationic DNA vector 1

  摘要：

  A glycosylated analogue of dialkylamidoglycylcarboxyspermine was synthesized. The physico-chemical and transfecting properties of 11 were evaluated indicating that this cationic lipid forms stable particles at low charge ratio and is efficient for gene delivery. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00683-1