2-acetyl-5-methylindan-1-one | 144067-31-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 2-acetyl-5-methylindan-1-one
• 英文别名: 2-Acetyl-5-methyl-2,3-dihydroinden-1-one
• CAS: 144067-31-2
• 化学式: C₁₂H₁₂O₂
• 分子量: 188.226
• InChiKey: LIJULYNBBBZDKF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 1-对甲苯基丁烷-1,3-二酮 在 乙基溴化镁 作用下， 生成 2-acetyl-5-methylindan-1-one
  参考文献：
  名称：

  Selective synthesis of 1-indanones via tandem knoevenagel condensation-cycloalkylation of β-dicarbonyl compounds and aldehydes

  摘要：

  Aromatic 1,3-dicarbonyl compounds react with not enolizable aldehydes in the presence of C2H5MgBr or AlCl3 affording 2-carbethoxy- and 2-acetyl-1-indanones via tandem Knoevenagel condensation-cycloalkylation process.

  DOI：

  10.1016/0040-4020(95)00772-z

文献信息

• Synthesis Of 1,5-Disubstituted-2-Hydroxy-Gibbatetraen-6-Ones
  申请人：Wilkening R. Robert

  公开号：US20070293706A1

  公开（公告）日：2007-12-20

  1,5-disubstituted-2-hydroxy-gibbatetraen-6-ones are useful as estrogen receptor modulators and as precursors to estrogen receptor modulators. The current invention provides a method for the synthesis of 1,5-disubstituted-2-hydroxy-gibbatetraen-6-ones from simple indanone starting materials via a Robinson-type annulation followed by an internal alkylation reaction. This invention further describes the novel use of a fluoroethyl substituent as a latent alkylating group for an internal cyclization reaction.

  1,5-二取代-2-羟基-吉巴四烯-6-酮可用作雌激素受体调节剂和雌激素受体调节剂的前体。本发明提供了一种从简单的茚酮起始材料通过罗宾逊型环化反应后内部烷基化反应合成1,5-二取代-2-羟基-吉巴四烯-6-酮的方法。本发明进一步描述了氟乙基取代基作为内部环化反应的潜在烷基化基团的新用途。
• Friedel-crafts coordinated processes: Highly selective synthesis of ethyl-1-oxo-2-indancarboxylates and 1-oxo-2-acetylindanes
  作者：Giovanni Sartori、Franca Bigi、Xiaochun Tao、Giuseppe Casnati、Giacomo Canali

  DOI：10.1016/s0040-4039(00)61282-0

  日期：1992.8

  Alkyl 1-oxo-2-indancarboxylates and 1-oxo-2-acetylindanes were synthesized in good yields by methylenation of aromatic beta-dicarbonyl compounds with MeOCH2COCl.AlCl3 reagent.
• Selective synthesis of 1-indanones via tandem knoevenagel condensation-cycloalkylation of β-dicarbonyl compounds and aldehydes
  作者：Giovanni Sartori、Raimondo Maggi、Franca Bigi、Cecilia Porta、Xiaochun Tao、Gian Luca Bernardi、Sandra Ianelli、Mario Nardelli

  DOI：10.1016/0040-4020(95)00772-z

  日期：1995.10

  Aromatic 1,3-dicarbonyl compounds react with not enolizable aldehydes in the presence of C2H5MgBr or AlCl3 affording 2-carbethoxy- and 2-acetyl-1-indanones via tandem Knoevenagel condensation-cycloalkylation process.