5'-O-t-butyldimethylsilyl-3'-carbomethoxymethyl-2',3'-dideoxyuridine | 161045-31-4

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 5'-O-t-butyldimethylsilyl-3'-carbomethoxymethyl-2',3'-dideoxyuridine
• 英文别名: methyl 2-[(2S,3R,5R)-2-[[tert-butyl(dimethyl)silyl]oxymethyl]-5-(2,4-dioxopyrimidin-1-yl)oxolan-3-yl]acetate
• CAS: 161045-31-4
• 化学式: C₁₈H₃₀N₂O₆Si
• 分子量: 398.531
• InChiKey: BDQIUUYSKFQCGP-UMVBOHGHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.03
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  94.2
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  5'-O-t-butyldimethylsilyl-3'-carbomethoxymethyl-2',3'-dideoxyuridine 在 4-二甲氨基吡啶 、 sodium azide 、 三乙胺 作用下， 以 1,2-二氯乙烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 生成 5'-O-t-butyldimethylsilyl-3'-carbomethoxymethyl-4-desamino-4-azido-2',3'-dideocytidine
  参考文献：
  名称：

  Synthesis of Deoxycytidine (dC) Building Blocks for Amide-Linked Dimers or Oligomers: Example of a Deoxycytidine-amide-thymidine Dimer

  摘要：

  5'-Azido-3'-carbomethoxymethyl-4-N-benzoyl-2',3',5'-trideoxy-cytidine 17 and 5'-O-t-butyldimethylsilyl-3'-carboxymethyl-4-N-benzoyl-2',3'-dideocytidine 22 were efficiently synthesized from 2'-deoxyuridine via a new method which transformed the uracil heterocycle to 4-N-benzoylcytosine (four steps, 60 % overall yield). The amide-linked deoxycytidine-thymidine dimer analog was synthesized.

  DOI：

  10.1080/15257779408010666
• 作为产物：
  描述：

  5'-O-(tert-butyldimethylsilyl)-3'-C-allyl-2',3'-dideoxyuridine 在 sodium periodate 、 四氧化锇 、 重铬酸吡啶 作用下， 以 乙醚 、 N,N-二甲基甲酰胺 为溶剂， 反应 7.0h， 生成 5'-O-t-butyldimethylsilyl-3'-carbomethoxymethyl-2',3'-dideoxyuridine
  参考文献：
  名称：

  Synthesis of Deoxycytidine (dC) Building Blocks for Amide-Linked Dimers or Oligomers: Example of a Deoxycytidine-amide-thymidine Dimer

  摘要：

  5'-Azido-3'-carbomethoxymethyl-4-N-benzoyl-2',3',5'-trideoxy-cytidine 17 and 5'-O-t-butyldimethylsilyl-3'-carboxymethyl-4-N-benzoyl-2',3'-dideocytidine 22 were efficiently synthesized from 2'-deoxyuridine via a new method which transformed the uracil heterocycle to 4-N-benzoylcytosine (four steps, 60 % overall yield). The amide-linked deoxycytidine-thymidine dimer analog was synthesized.

  DOI：

  10.1080/15257779408010666

文献信息

• Synthesis of Deoxycytidine (dC) Building Blocks for Amide-Linked Dimers or Oligomers: Example of a Deoxycytidine-amide-thymidine Dimer
  作者：Evelyne Grunder-Klotz、George Just

  DOI：10.1080/15257779408010666

  日期：1994.9

  5'-Azido-3'-carbomethoxymethyl-4-N-benzoyl-2',3',5'-trideoxy-cytidine 17 and 5'-O-t-butyldimethylsilyl-3'-carboxymethyl-4-N-benzoyl-2',3'-dideocytidine 22 were efficiently synthesized from 2'-deoxyuridine via a new method which transformed the uracil heterocycle to 4-N-benzoylcytosine (four steps, 60 % overall yield). The amide-linked deoxycytidine-thymidine dimer analog was synthesized.