2-amine-3-pentanol | 116836-16-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-amine-3-pentanol
• 英文别名: (β-oxy-α-methyl-butyl)-amine；Aethyl-(α-amino-aethyl)-carbinol；2-amino-3-pentanol；aminoethylpropanol；1,3-dimethylamino propan-2-ol；2-Aminopentan-3-ol
• CAS: 116836-16-9
• 化学式: C₅H₁₃NO
• mdl: MFCD20232890
• 分子量: 103.164
• InChiKey: JPGZDACJIPHKML-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-amine-3-pentanol 在 四(三苯基膦)钯 molecular sieve 、 2-溴-1,3,5-三甲基苯 、 三溴化硼 、 potassium carbonate 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 14.0h， 生成 3-ethyl-2-methyl-6-hydroxymethyl-4,5,6,7-tetrahydroindol-4-one
  参考文献：
  名称：

  New synthetic approaches to CNS drugs. A straightforward, efficient synthesis of tetrahydroindol-4-ones and tetrahydroquinolin-5-ones via palladium-catalyzed oxidation of hydroxyenaminones

  摘要：

  We have developed a facile and efficient synthesis of new conformationally restricted butyrophenones in the indole and quinoline series via palladium-catalyzed oxidation of hydroxyenaminones, and subsequent cyclization followed by spontaneous arornatization. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)01901-9
• 作为产物：
  描述：

  戊烷-2,3-二酮 2-肟 在 lithium aluminium tetrahydride 作用下， 生成 2-amine-3-pentanol
  参考文献：
  名称：

  New synthetic approaches to CNS drugs. A straightforward, efficient synthesis of tetrahydroindol-4-ones and tetrahydroquinolin-5-ones via palladium-catalyzed oxidation of hydroxyenaminones

  摘要：

  We have developed a facile and efficient synthesis of new conformationally restricted butyrophenones in the indole and quinoline series via palladium-catalyzed oxidation of hydroxyenaminones, and subsequent cyclization followed by spontaneous arornatization. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)01901-9

文献信息

• One-pot Synthesis, Crystal structure, and Bioactivity of<i>N</i>-Phenoxyacetyl-2,4,5-trisubstituted-1,3-oxazolidines
  作者：Ying Fu、Wen-Geng Chen、Yu-Wen Hou、Bin Wang、Li-Xia Zhao、Fei Ye

  DOI：10.1002/jhet.2706

  日期：2017.3

  N‐phenoxyacetyl‐1,3‐oxazolidine derivatives were synthesized by the cyclization and acylation with β‐amino alcohol, ketone, and phenoxyacetyl chloride as the starting materials. All compounds were characterized by IR, 1H NMR, 13C NMR, ESI‐MS, and elemental analysis. The configuration of 4a was determined by X‐ray crystallography. The preliminary biological tests showed that all products could protect

  N-苯氧基乙酰基-1,3-恶唑烷衍生物是通过以β-氨基醇，酮和苯氧基乙酰氯为原料的环化和酰化反应合成的。所有化合物均通过IR，1 H NMR，13 C NMR，ESI-MS和元素分析进行了表征。4a的构型由X射线晶体学确定。初步的生物学测试表明，所有产品都可以在一定程度上保护大豆免受2,4-D丁酸酯的伤害。
• Tordoir, Chemisches Zentralblatt, 1902, vol. 73, # I, p. 716
  作者：Tordoir

  DOI：——

  日期：——
• An efficient reduction protocol for the synthesis of β-hydroxycarbamates from β-nitro alcohols in one pot: a facile synthesis of (−)-β-conhydrine
  作者：Partha Pratim Saikia、Gakul Baishya、Abhishek Goswami、Nabin C. Barua

  DOI：10.1016/j.tetlet.2008.08.113

  日期：2008.11

  An efficient and practical one-pot protocol for the reduction of beta-nitro alcohols to their corresponding N-(tert-butoxycarbonyl) amino alcohols using Zn-NH4Cl in aqueous methanol is described. Other reducible groups such as ketones and isolated double bonds remained intact. This methodology allows a short synthesis of (-)-beta-conhydrine to be achieved. (C) 2008 Elsevier Ltd. All rights reserved.
• Jaenecke, Chemische Berichte, 1899, vol. 32, p. 1096
  作者：Jaenecke

  DOI：——

  日期：——
• Microwave-Assisted Synthesis and Bioactivity of Novel 2,2,4,5-Tetrasubstituted 3-Dichloroacetyl-1,3-oxazolidines
  作者：Fei Ye、Lei Yang、Ying Fu、Shuang Gao

  DOI：10.3987/com-11-12326

  日期：——

  An efficient one-pot synthesis of 2,2,4,5-tetrasubstituted 3-dichloroacetyl-1,3-oxazolidines under microwave irradiation was developed. The intermediate oxazolidines were attained by the reaction of amino alcohol with aldehyde or ketone in refluxing benzene with microwave-assisted cycloaddition, and then the acylation followed with dichloroacetyl chloride and NaOH acting as the attaching acid agent. All the compounds were characterized by FR, H-1-NMR, C-13-NMR and elemental analysis. The preliminary biological test shows that these compounds could protect maize against injury caused by acetochlor to a certain extent.