benzyl N-[(2S)-1-[(1,3-dioxoisoindol-2-yl)amino]-4-methyl-1-oxopentan-2-yl]carbamate | 827624-67-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: benzyl N-[(2S)-1-[(1,3-dioxoisoindol-2-yl)amino]-4-methyl-1-oxopentan-2-yl]carbamate
• CAS: 827624-67-9
• 化学式: C₂₂H₂₃N₃O₅
• 分子量: 409.442
• InChiKey: QGJHBCCGYKUXLJ-SFHVURJKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  105
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  O^α-(tetrahydropyran-2-yl)-L-lactic acid 、 benzyl N-[(2S)-1-[(1,3-dioxoisoindol-2-yl)amino]-4-methyl-1-oxopentan-2-yl]carbamate 以44%的产率得到N-(((benzyloxy)carbonyl)-L-leucyl)-N-(1,3-dioxoisoindolin-2-yl)-D-alanine
  参考文献：
  名称：

  Oligomerization of N-aminodipeptides: to the synthesis of heterogeneous backbone with 1:1 α:α-N-amino aminoacid residue patterns

  摘要：

  A large number of N-aminodipeptides compounds have been obtained via a Mitsunobu protocol performed in Solution or by solid-phase synthesis. The oligomerization of some of them has been studied in solution or on solid support leading to the formation of 1:1[alpha:alpha-N-amino]mers. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.08.087
• 作为产物：
  描述：

  苄氧羰基-亮氨酸甲酯 在 一水合肼 作用下， 以 甲醇 、 甲苯 为溶剂， 反应 18.0h， 生成 benzyl N-[(2S)-1-[(1,3-dioxoisoindol-2-yl)amino]-4-methyl-1-oxopentan-2-yl]carbamate
  参考文献：
  名称：

  A family of strong low-molecular-weight organogelators based on aminoacid derivatives

  摘要：

  A new family of potent aminoacid-type organogelators obtained via an easy and unexpensive way is described. We demonstrated that structural variations onto the side chains of the aminoacid derivatives allowed modulations of the gelation properties. The organogelators bearing a benzyl or an isopropyl group (compounds 1e, 2a, and 2c) are able to provide gelation of apolar solvents at very low concentration ( less than or equal to 0.2 wt%) and to form thermostable gels. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.10.139

文献信息

• A family of strong low-molecular-weight organogelators based on aminoacid derivatives
  作者：Nicolas Brosse、Danielle Barth、Brigitte Jamart-Grégoire

  DOI：10.1016/j.tetlet.2004.10.139

  日期：2004.12

  A new family of potent aminoacid-type organogelators obtained via an easy and unexpensive way is described. We demonstrated that structural variations onto the side chains of the aminoacid derivatives allowed modulations of the gelation properties. The organogelators bearing a benzyl or an isopropyl group (compounds 1e, 2a, and 2c) are able to provide gelation of apolar solvents at very low concentration ( less than or equal to 0.2 wt%) and to form thermostable gels. (C) 2004 Elsevier Ltd. All rights reserved.
• Oligomerization of N-aminodipeptides: to the synthesis of heterogeneous backbone with 1:1 α:α-N-amino aminoacid residue patterns
  作者：Anne-Sophie Felten、Sébastien Dautrey、Jacques Bodiguel、Régis Vanderesse、Claude Didierjean、Axelle Arrault、Brigitte Jamart-Grégoire

  DOI：10.1016/j.tet.2008.08.087

  日期：2008.11

  A large number of N-aminodipeptides compounds have been obtained via a Mitsunobu protocol performed in Solution or by solid-phase synthesis. The oligomerization of some of them has been studied in solution or on solid support leading to the formation of 1:1[alpha:alpha-N-amino]mers. (C) 2008 Elsevier Ltd. All rights reserved.