2-[4-(1,3-Dithiolan-2-yl)phenyl]-1,3-thiazole-4-carbohydrazide | 263252-33-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-[4-(1,3-Dithiolan-2-yl)phenyl]-1,3-thiazole-4-carbohydrazide
• CAS: 263252-33-1
• 化学式: C₁₃H₁₃N₃OS₃
• 分子量: 323.5
• InChiKey: PLOAVRYKWGGMKH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  147
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  5-(4-氯苯胺甲基)噻吩-2-磺酰氯 、 2-[4-(1,3-Dithiolan-2-yl)phenyl]-1,3-thiazole-4-carbohydrazide 、 吡啶 在 SiO2 作用下， 以 氯仿 为溶剂， 反应 2.0h， 以yielded 80% of the desired sulfonyl hydrazide 1的产率得到4-chloro-N-[(5-{[2-({2-[4-(1,3-dithiolan-2-yl)phenyl]-1,3-thiazol-4-yl}carbonyl)-hydrazino]sulfonyl}thien-2-yl)methyl]benzamide
  参考文献：
  名称：

  Pharmaceutically active sulfonyl hydrazide derivatives

  摘要：

  根据公式I，其几何异构体，光学活性对映体，差向异构体，外消旋体和/或药学上可接受的盐的磺酰肼类化合物在治疗需要此类治疗的患者的神经紊乱，自身免疫疾病，心血管疾病或癌症的方法中是有用的。

  公开号：

  US08017628B2

文献信息

• PHARMACEUTICALLY ACTIVE SULFONYL HYDRAZIDE DERIVATIVES
  申请人：ARKINSTALL Stephen

  公开号：US20090005426A1

  公开（公告）日：2009-01-01

  Sulfonyl hydrazide compounds according to formula I geometrical isomers thereof, optically active enantiomers thereof, diastereomers thereof, racemates thereof, and/or pharmaceutically acceptable salts thereof are useful in method for treating a neuronal disorder, an autoimmune disease, a cardiovascular disease, or cancer in a patient in need of such treatment.

  根据I式的磺酰肼化合物及其几何异构体、光学活性对映体、差向异构体、外消旋体和/或药学上可接受的盐，在治疗神经性疾病、自身免疫性疾病、心血管疾病或癌症的方法中，对于需要此类治疗的患者是有用的。
• US7432286B1
  申请人：——

  公开号：US7432286B1

  公开（公告）日：2008-10-07
• US8017628B2
  申请人：——

  公开号：US8017628B2

  公开（公告）日：2011-09-13
• [EN] PHARMACEUTICALLY ACTIVE SULFONYL HYDRAZIDE DERIVATIVES<br/>[FR] DERIVES DE SULFONYL HYDRAZIDE ACTIFS AU PLAN PHARMACEUTIQUE
  申请人：APPLIED RESEARCH SYSTEMS

  公开号：WO2001023382A1

  公开（公告）日：2001-04-05

  The present invention is related to sulfonyl hydrazide derivatives for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such sulfonyl hydrazide derivatives. Said sulfonyl hydrazide derivatives are efficient modulators of the JNK pathway, they are in particular efficient inhibitors of JNK 2 and 3. The present invention is furthermore related to novel sulfonyl hydrazide derivatives as well as to methods of their preparation. In Formula (I) Ar?1 and Ar2¿ are independently from each other an unsubstituted or substituted aryl or heteroaryl group, X?1 and X2¿ are independently from each other O or S; R?1, R2, R3¿ are independently from each other hydrogen or a C¿1?-C6-alkyl substituent or R?1¿ forms a substituted or unsubstituted 5-6-membered saturated or unsaturated ring with Ar?1; or R2 and R3¿ form a substituted or unsubstituted 5-6-membered saturated or unsaturated ring; n is an integer from 0 to 5; G is selected from a group comprising or consisting of an unsubstituted or substituted 4-8 membered heterocycle containing at least one heteroatom, or G is a substituted or unsubstituted C¿1?-C6-alkyl group.
• Pharmaceutically active sulfonyl hydrazide derivatives
  申请人：Applied Research Systems ARS Holding N.V.

  公开号：EP1088822A1

  公开（公告）日：2001-04-04

  The present invention is related to sulfonyl hydrazide derivatives according to formula I with its geometrical isomers, in an optically active form as enantiomers, diastereomers, as well as in the form of racemates, as well as pharmaceutically acceptable salts thereof, wherein Ar1 and Ar2 are independently from each other an unsubstituted or substituted aryl or heteroaryl group, X1 and X2 are independently from each other O or S; R1, R2, R3 are independently from each other hydrogen or a C1-C6-alkyl substituent or R1 forms a substituted or unsubstituted 5-6-membered saturated or unsaturated ring with Ar1; or R2 and R3 form a substituted or unsubstituted 5-6-membered saturated or unsaturated ring; n is an integer from 0 to 5; G is selected from a group comprising or consisting of an unsubstituted or substituted 4-8-membered heterocycle containing at least one heteroatom, or G is a substituted or unsubstituted C1-C6-alkyl group; for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such sulfonyl hydrazide derivatives. Said sulfonyl hydrazide derivatives are efficient modulators of the JNK pathway, they are in particular efficient inhibitors of JNK 2 and 3. The present invention is furthermore related to novel sulfonyl hydrazide derivatives as well as to methods of their preparation.

  本发明涉及按照式I的磺酰基腙衍生物及其几何异构体，以对映体、二对映体的光学活性形式，以及它们的盐的药学上可接受的形式，其中Ar1和Ar2分别独立地是未取代或取代的芳基或杂环芳基，X1和X2分别独立地是O或S；R1、R2、R3分别独立地是氢或C1-C6-烷基取代基，或R1与Ar1形成取代或未取代的5-6元饱和或不饱和环；或R2和R3形成取代或未取代的5-6元饱和或不饱和环；n是0到5的整数；G选自包含或仅包含至少一个杂原子的未取代或取代的4-8元杂环的群，或G是取代或未取代的C1-C6烷基基团；用作药学活性化合物，以及含有这种磺酰基腙衍生物的制药配方。所述磺酰基腙衍生物是JNK途径的高效调节剂，特别是JNK 2和3的高效抑制剂。本发明还涉及新型磺酰基腙衍生物以及其制备方法。