ethyl 2-(dimethylamino)-4-hydroxy-1,3-thiazole-5-carboxylate | 1178558-39-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: ethyl 2-(dimethylamino)-4-hydroxy-1,3-thiazole-5-carboxylate
• 英文别名: Ethyl 2-(dimethylamino)-4-hydroxy-1,3-thiazole-5-carboxylate
• CAS: 1178558-39-8
• 化学式: C₈H₁₂N₂O₃S
• 分子量: 216.261
• InChiKey: JAJCOYJIABTWSP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  90.9
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  氯代丙二酸二乙酯 、 N,N-二甲基硫脲 在 1-正丁基-3-甲基咪唑三氟甲烷磺酸盐 作用下， 以70%的产率得到ethyl 2-(dimethylamino)-4-hydroxy-1,3-thiazole-5-carboxylate
  参考文献：
  名称：

  A one-pot synthesis of functionalized ethyl 1,3-thiazole-5-carboxylates from thioamides or thioureas and 2-chloro-1,3-dicarbonyl compounds in an ionic liquid

  摘要：

  A simple one-pot synthesis of functionalized ethyl 1,3-thiazole-5-carboxylates from the reaction of 2-chloro-1,3-dicarbonyl compounds with thioureas or thio-amidesin the presence of 1-butyl-3-methylimidazolium trifluoromethanesulfonate is described.

  DOI：

  10.1007/s00706-008-0065-7

文献信息

• A one-pot synthesis of functionalized ethyl 1,3-thiazole-5-carboxylates from thioamides or thioureas and 2-chloro-1,3-dicarbonyl compounds in an ionic liquid
  作者：Issa Yavari、S. Zahra Sayyed-Alangi、Rahimeh Hajinasiri、Hadi Sajjadi-Ghotbabadi

  DOI：10.1007/s00706-008-0065-7

  日期：2009.2

  A simple one-pot synthesis of functionalized ethyl 1,3-thiazole-5-carboxylates from the reaction of 2-chloro-1,3-dicarbonyl compounds with thioureas or thio-amidesin the presence of 1-butyl-3-methylimidazolium trifluoromethanesulfonate is described.