2-(4-(3-bromopropoxy)phenyl)benzofuran | 258875-77-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 2-芳基苯并呋喃类黄酮
• 英文名称: 2-(4-(3-bromopropoxy)phenyl)benzofuran
• 英文别名: 2-[4-(3-Bromopropoxy)phenyl]-1-benzofuran
• CAS: 258875-77-3
• 化学式: C₁₇H₁₅BrO₂
• 分子量: 331.209
• InChiKey: AOBXAWMYXRUDAT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  22.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(4-(3-bromopropoxy)phenyl)benzofuran 在 四氯化锡 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 生成 3-p-toluoyl-2-[4'-(3-diethylaminopropoxy)-phenyl]-benzofuran
  参考文献：
  名称：

  A short synthesis of the β-amyloid (Aβ) aggregation inhibitor 3-p-Toluoyl-2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran

  摘要：

  A short and convenient synthesis of 3-p-toluoyl-2-[4'-(3-diethylaminopropoxy)-phenyl]- benzofuran, an inhibitor of the aggregation of beta-amyloid, which is thought to be the underlying cause of Alzheimer's disease, is described. (C) 1999 Elsevier Science Ltd. Ali rights reserved.

  DOI：

  10.1016/s0040-4039(99)02030-4
• 作为产物：
  描述：

  2-(4-甲氧基苯基)苯并呋喃 在 三溴化硼 、 potassium carbonate 作用下， 以 二氯甲烷 、 丙酮 为溶剂， 生成 2-(4-(3-bromopropoxy)phenyl)benzofuran
  参考文献：
  名称：

  A short synthesis of the β-amyloid (Aβ) aggregation inhibitor 3-p-Toluoyl-2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran

  摘要：

  A short and convenient synthesis of 3-p-toluoyl-2-[4'-(3-diethylaminopropoxy)-phenyl]- benzofuran, an inhibitor of the aggregation of beta-amyloid, which is thought to be the underlying cause of Alzheimer's disease, is described. (C) 1999 Elsevier Science Ltd. Ali rights reserved.

  DOI：

  10.1016/s0040-4039(99)02030-4

文献信息

• Inhibition of cholinesterase activity and amyloid aggregation by berberine-phenyl-benzoheterocyclic and tacrine-phenyl-benzoheterocyclic hybrids
  作者：Ling Huang、Tao Su、Wenjun Shan、Zonghua Luo、Yang Sun、Feng He、Xingshu Li

  DOI：10.1016/j.bmc.2012.02.059

  日期：2012.5

  A series of berberine-phenyl-benzoheterocyclic (26-29) and tacrine-phenyl-benzoheterocyclic hybrids (44-46) were synthesised and evaluated as multifunctional anti-Alzheimer's disease agents. Compound 44b, tacrine linked with phenyl-benzothiazole by 3-carbon spacers, was the most potent AChE inhibitor with an IC50 value of 0.017 mu M. This compound demonstrated similar A beta aggregation inhibitory activity with cucurmin (51.8% vs 52.1% at 20 mu M, respectively), indicating that this hybrid is an excellent multifunctional drug candidate for AD. (C) 2012 Elsevier Ltd. All rights reserved.
• A short synthesis of the β-amyloid (Aβ) aggregation inhibitor 3-p-Toluoyl-2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran
  作者：Lance J. Twyman、David Allsop

  DOI：10.1016/s0040-4039(99)02030-4

  日期：1999.12

  A short and convenient synthesis of 3-p-toluoyl-2-[4'-(3-diethylaminopropoxy)-phenyl]- benzofuran, an inhibitor of the aggregation of beta-amyloid, which is thought to be the underlying cause of Alzheimer's disease, is described. (C) 1999 Elsevier Science Ltd. Ali rights reserved.