1-[5-Tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-[[2-(pyrazin-2-ylamino)pyridin-4-yl]methoxy]naphthalen-1-yl]urea

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-[5-Tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-[[2-(pyrazin-2-ylamino)pyridin-4-yl]methoxy]naphthalen-1-yl]urea
• 英文别名: 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-[[2-(pyrazin-2-ylamino)pyridin-4-yl]methoxy]naphthalen-1-yl]urea
• 化学式: C₃₅H₃₄N₈O₂
• 分子量: 598.7
• InChiKey: AZFIHZPEFANPSQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  45
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  119
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• AROMATIC HETEROCYCLIC COMPOUNDS AS ANTIINFLAMMATORY COMPOUNDS
  申请人：Respivert Limited

  公开号：EP3418279A1

  公开（公告）日：2018-12-26

  There are provided compounds of formula (I) as defined in the specification which are p38 MAP kinase inhibitors for use as medicaments for the treatment inter alia of inflammatory diseases.

  本说明书中定义的式 (I) 化合物是 p38 MAP 激酶抑制剂，可用作治疗炎症等疾病的药物。
• Pyrazolyl ureas as kinase inhibitors
  申请人：RESPIVERT LIMITED

  公开号：US10294216B2

  公开（公告）日：2019-05-21

  There are provided compounds of formula (I) shown below as defined in the specification which are p38 MAP kinase inhibitors for use as medicaments for the treatment inter alia of inflammatory diseases.

  本说明书中定义的下式（I）化合物是 p38 MAP 激酶抑制剂，可用作治疗炎症等疾病的药物。
• Pyrazolyl-ureas as kinase inhibitors
  申请人：RESPIVERT LIMITED

  公开号：US11142515B2

  公开（公告）日：2021-10-12

  There are provided compounds of formula (I) as defined in the specification which are p38 MAP kinase inhibitors for use as medicaments for the treatment inter alia of inflammatory diseases.

  本说明书中定义的式 (I) 化合物是 p38 MAP 激酶抑制剂，可用作治疗炎症等疾病的药物。
• PYRAZOLYL-UREAS AS KINASE INHIBITORS
  申请人：Respivert Limited

  公开号：EP3105223A1

  公开（公告）日：2016-12-21
• DRY POWDER PHARMACEUTICAL FORMULATION
  申请人：Respivert Limited

  公开号：EP3418279B1

  公开（公告）日：2021-01-20