1,3-Dihydroxypropan-2-yl heptadecanoate | 118605-13-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: 1,3-Dihydroxypropan-2-yl heptadecanoate
• CAS: 118605-13-3
• 化学式: C₂₀H₄₀O₄
• 分子量: 344.535
• InChiKey: FYVRRADTEFDJIB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  24
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  十七烷酸 、 (9Z,12Z,15Z)-octadeca-9,12,15-trienoic acid cis-2-phenyl-[1,3]dioxan-5-yl ester 在 三氟乙酸酐 、 porcine pancreatin 、 水 、 sodium cholate 、 calcium chloride 作用下， 以 二氯甲烷 为溶剂， 反应 72.0h， 生成 glyceryl 2-linolenate 、 1,3-Dihydroxypropan-2-yl heptadecanoate
  参考文献：
  名称：

  Rapid access to structured triacylglycerols acylated with n-3 polyunsaturated fatty acids for nutritional applications

  摘要：

  In order to better understand the metabolic fate of n-3 polyunsaturated fatty acids (PUFAs), an efficient access to symmetrical and unsymmetrical triacylglycerols (TGs), esterified with PUFAs, with known high purity, is required. In this context, we optimized the esterification of a mixture of glycerols protected as dioxane and dioxolane with PUFAs. The kinetics of this reaction depends on various factors, such as the fatty acid chain length and the stereochemistry of the dioxane. Then, one-pot acetal hydrolysis and esterification of hydroxyl groups led to the desired structured TGs without either double bond isomerization or acyl migration (except when symmetrical TGs are acylated with long-chain saturated fatty acids in external positions). PUFAs location on the glycerol backbone was assayed by NMR, HPLC and pancreatic lipase hydrolysis. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.09.070

文献信息

• Probe compound for detecting and isolating enzymes and means and methods using the same
  申请人：Helmholtz-Zentrum für Infektionsforschung GmbH

  公开号：EP2230312A1

  公开（公告）日：2010-09-22

  The present invention relates to a probe compound that can comprise any substrate or metabolite of an enzymatic reaction in addition to an indicator component, such as, for example, a fluorescence dye, or the like. Moreover, the present invention relates to means for detecting enzymes in form of an array, which comprises any number of probe compounds of the invention which each comprise a different metabolite of interconnected metabolites representing the central pathways in all forms of life. Moreover, the present invention relates to a method for detecting enzymes involving the application of cell extracts or the like to the array of the invention which leads to reproducible enzymatic reactions with the substrates. These specific enzymatic reactions trigger the indicator (e.g. a fluorescence signal) and bind the enzymes to the respective cognate substrates. Moreover, the invention relates to means for isolating enzymes in form of nanoparticles coated with the probe compound of the invention. The immobilisation of the cognate substrates or metabolites on the surface of nanoparticles by means of the probe compounds allows capturing and isolating the respective enzyme, e.g. for subsequent sequencing.

  本发明涉及一种探针化合物，它可以包括酶反应的任何底物或代谢物，此外还包括指示成分，例如荧光染料或类似物。此外，本发明还涉及以阵列形式检测酶的方法，该阵列由任意数量的本发明探针化合物组成，每种探针化合物由代表所有生命形式中中心途径的相互关联的代谢物中的不同代谢物组成。此外，本发明还涉及一种检测酶的方法，该方法涉及将细胞提取物或类似物应用于本发明的阵列，从而导致与底物发生可重复的酶反应。这些特定的酶反应会触发指示剂（如荧光信号），并将酶与各自的同源底物结合。此外，本发明还涉及以涂覆有本发明探针化合物的纳米颗粒形式分离酶的方法。通过探针化合物将同源底物或代谢物固定在纳米颗粒表面，可以捕获和分离相应的酶，例如用于后续测序。
• POLOXAMER COMPOSITIONS WITH REDUCED SOL-GEL TRANSITION TEMPERATURES AND METHODS OF REDUCING THE SOL-GEL TRANSITION TEMPERATURE OF POLOXAMER COMPOSITIONS
  申请人：Rochal Technologies LLC

  公开号：EP4051239A1

  公开（公告）日：2022-09-07
• AROMATIC POLYSULFONE RESIN COMPOSITION AND MOLDED ARTICLE THEREOF
  申请人：SAITO Shintaro

  公开号：US20110245394A1

  公开（公告）日：2011-10-06

  An aromatic polysulfone resin composition including an aromatic polysulfone resin and at least one compound selected from the group consisting of a monoacylglycerol, a diacylglycerol and a triacylglycerol, wherein the amount of the at least one compound, relative to 100 parts by weight of the aromatic polysulfone resin is preferably 0.02 to 4 parts by weight, and the aromatic polysulfone resin composition is preferably in the form of pellet obtained by subjecting the aromatic polysulfone resin and the at least one compound to melt-kneading.
• Poloxamer Compositions With Reduced Sol-Gel Transition Temperatures and Methods of Reducing the Sol-Gel Transition Temperature of Poloxamer Compositions
  申请人：ROCHAL INDUSTRIES, LLC

  公开号：US20210121575A1

  公开（公告）日：2021-04-29

  The reduction in the sol-gel temperature of aqueous poloxamer surfactant compositions by the addition of hydrophobic vicinal diols is provided. Lowering of the sol-gel temperature and the gelling efficiency of water-soluble poloxamer block copolymers of polyethylene oxide-b-polypropylene oxide-b-polyethylene oxide has been markedly improved by the addition of small amounts of at least one hydrophobic vicinal diol, such as monoalkyl glycols, monoalkyl glycerols, or monoacyl glycerols. The decrease in the sol-gel temperature facilitates gel formation, and such gels exhibit greater residence time on a surface, particularly those with biological properties.
• [EN] METHODS FOR REDUCING THE TEMPERATURE OF SOL-GEL TRANSITIONS<br/>[FR] PROCÉDÉS DE RÉDUCTION DE LA TEMPÉRATURE DE TRANSITIONS SOL-GEL
  申请人：ROCHAL IND LLC

  公开号：WO2021086698A1

  公开（公告）日：2021-05-06

  The reduction in the sol-gel temperature of aqueous poloxamer surfactant compositions by the addition of hydrophobic vicinal diols is provided. Lowering of the sol-gel temperature and the gelling efficiency of water-soluble poloxamer block copolymers of polyethylene oxide-b- polypropylene oxide-b-polyethylene oxide has been markedly improved by the addition of small amounts of at least one hydrophobic vicinal diol, such as monoalkyl glycols, monoalkyl glycerols, or monoacyl glycerols. The decrease in the sol-gel temperature facilitates gel formation, and such gels exhibit greater residence time on a surface, particularly those with biological properties.