1-phenylpentadecan-2-ol | 19366-24-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 1-phenylpentadecan-2-ol
• CAS: 19366-24-6
• 化学式: C₂₁H₃₆O
• 分子量: 304.516
• InChiKey: AGBBGTVXWHHJAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.2
• 重原子数：
  22
• 可旋转键数：
  14
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  肉豆蔻醛 、 溴甲苯 在 copper(II) choride dihydrate 、 magnesium 作用下， 以 四氢呋喃 为溶剂， 反应 16.0h， 以57.8%的产率得到1-phenylpentadecan-2-ol
  参考文献：
  名称：

  A simple and inexpensive procedure for low valent copper mediated benzylation of aldehydes in wet medium: synthesis of protease inhibitor synthon

  摘要：

  An operationally simple, inexpensive and efficient procedure for benzylation of aldehydes in wet medium has been developed that was mediated with low valent copper, prepared in situ through spontaneous reduction of CuCl2-2H(2)O with magnesium in situ. Notably, copper mediated benzylation of 3h took place with good syn selectivity that was opposite to that for the corresponding Grignard addition. Finally, homobenzyl alcohol 5a was elegantly transformed into a known protease inhibitor synthon I.

  DOI：

  10.3998/ark.5550190.0011.912

文献信息

• TEILESTER VON 2-BENZYLALKANOLEN-(1) UND 2-BENZYLALKANOL-1-POLYGLYKOLETHERN SOWIE VERFAHREN ZU IHRER HERSTELLUNG
  申请人：Henkel Kommanditgesellschaft auf Aktien

  公开号：EP0224523B1

  公开（公告）日：1989-03-01
• A simple and inexpensive procedure for low valent copper mediated benzylation of aldehydes in wet medium: synthesis of protease inhibitor synthon
  作者：Angshuman Chattopadhyay、Akhil Dubey、Dibakar Goswami

  DOI：10.3998/ark.5550190.0011.912

  日期：——

  An operationally simple, inexpensive and efficient procedure for benzylation of aldehydes in wet medium has been developed that was mediated with low valent copper, prepared in situ through spontaneous reduction of CuCl2-2H(2)O with magnesium in situ. Notably, copper mediated benzylation of 3h took place with good syn selectivity that was opposite to that for the corresponding Grignard addition. Finally, homobenzyl alcohol 5a was elegantly transformed into a known protease inhibitor synthon I.