N-phenyl-1H-pyrazole-1-carboxamide | 27257-97-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-phenyl-1H-pyrazole-1-carboxamide
• 英文别名: N-phenylpyrazole-1-carboxamide
• CAS: 27257-97-2
• 化学式: C₁₀H₉N₃O
• 分子量: 187.201
• InChiKey: UQMSSNPGHUMLNM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  46.9
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• PHARMACEUTICAL COMPOUNDS
  申请人：Kiss Laszlo Erno

  公开号：US20120065191A1

  公开（公告）日：2012-03-15

  The invention relates to compounds and compositions for inhibiting the enzyme fatty acid amide hydrolase (FAAH), the use of the compounds in therapy and, in particular, for treating or preventing conditions whose development or symptoms are linked to substrates of the FAAH enzyme, and methods of treatment or prevention using the compounds and compositions.

  这项发明涉及抑制脂肪酰胺水解酶（FAAH）的化合物和组合物，以及在治疗中使用这些化合物，特别是用于治疗或预防与FAAH酶底物相关的疾病的发展或症状的条件，以及使用这些化合物和组合物进行治疗或预防的方法。
• [EN] PROCESS FOR PREPARING ANTHRANILAMIDE ESTERS AND DERIVATIVES<br/>[FR] PROCÉDÉ DE PRÉPARATION D'ESTERS ET DE DÉRIVÉS D'ANTHRANILAMIDE
  申请人：BASF SE

  公开号：WO2015162260A1

  公开（公告）日：2015-10-29

  The present invention relates to a process for preparing N-pyridylpyrazole carboxanilides carrying a sulfiminocarbonyl group in the ortho position with respect to the amide group, which are represented by formula (I), the process comprising reacting a N-pyridylpyrazole carbooxanilide precursor of formula (II) or (II*) with a sulfimine of formula (III) or a salt thereof. Moreover, the present invention relates to a process for preparing N-pyridylpyrazole carbooxanilide precursors of formula (II) by reacting a compound of formula (IV) with a compound of formula (V). Furthermore, the present invention relates to N-pyridylpyrazole carbooxanilide precursors of formulae (II.A'), (II*.A'), (II.A'') and (II*.A'').

  本发明涉及一种制备携带与酰胺基相对位置上的磺酰亚胺羰基的N-吡啶基吡唑羧酰胺的过程，其由式(I)所代表，所述过程包括将式(II)或(II*)的N-吡啶基吡唑羧酰胺前体与式(III)的磺酰亚胺或其盐反应。此外，本发明涉及一种通过将式(IV)的化合物与式(V)的化合物反应制备式(II)的N-吡啶基吡唑羧酰胺前体的过程。此外，本发明涉及式(I.A')、(II*.A')、(II.A'')和(II*.A'')的N-吡啶基吡唑羧酰胺前体。
• [EN] PROCESS FOR THE PREPARATION OF ESTERS OF 4-FLUOROSUBSTITUTED 3-OXO-ALCANOIC ACIDS<br/>[FR] PROCÉDÉ DE PRÉPARATION D'ESTERS D'ACIDES 3-OXO-ALCANOÏQUES SUBSTITUÉS PAR FLUORO EN POSITION 4
  申请人：SOLVAY

  公开号：WO2009021987A1

  公开（公告）日：2009-02-19

  Esters of 4-fluorosubstituted 3-oxo-alcanoic acids can be prepared by addition reaction of ketene with the respective acid chloride, subsequent esterification and hydrodechlorination. Preferred reaction products are esters of 4,4- difluoro-3-oxo-butanoic acid.

  4-氟取代的3-酮-羧酸酯可以通过酮与相应酸氯加成反应、随后的酯化和脱氯化反应制备。首选的反应产物是4,4-二氟-3-酮丁酸酯。
• [EN] PROCESS FOR THE PREPARATION OF 4,4-DIFLUORO-3-OXOBUTANOIC ACID ESTERS<br/>[FR] PROCEDE DE PREPARATION D'ESTERS D'ACIDE 4,4-DIFLUORO-3-OXOBUTANOIQUE
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2006005612A1

  公开（公告）日：2006-01-19

  The present invention relates to a process for the preparation of a compound of the formula (I), wherein R is C1-12 alkyl, by the contact of a compound of the general formula (II) , wherein R1 and R2 are each, independently, C1-12 alkyl; or R1 and R2 join together with the nitrogen atom to which they are attached to form an alicyclic amine ring containing 4 to 7 carbon atoms or a morpholine ring, with an acetic acid ester of the general formula (III) CH3COOR, wherein R is as defined under formula (I), in the presence of a base.

  本发明涉及一种制备式(I)化合物的方法，其中R为C1-12烷基，通过将一般式(II)化合物与一般式(III)CH3COOR的乙酸酯在碱的存在下接触，其中R1和R2各自独立地为C1-12烷基；或者R1和R2与它们连接的氮原子结合在一起形成含有4到7个碳原子的脂环胺环或吗啉环。
• [EN] HETEROYCLYLPHENYL-AND HETEROCYCLYLPYRIDYL-SUBSTITUTED AZOLECARBOXAMIDES AS HERBICIDES<br/>[FR] AZOLECARBOXAMIDES SUBSTITUES PAR HETEROCYCLYLPHENYLE ET HETEROCYCLYLPYRIDILE
  申请人：DU PONT

  公开号：WO2005040152A1

  公开（公告）日：2005-05-06

  Compounds of Formula (I), and their N-oxides and agriculturally suitable salts, are disclosed which are useful for controlling undesired vegetation : wherein (J) is (J-1), (J-2), (J-3), (J-4), (J-5), (J-6), (J-7), (J-8), or (J-9) ; R5 is a phenyl ring or a 5- or 6-membered heteroaromatic ring which includes at least one heteroatom selected from N, O and S, each ring optionally substituted with one or more substituents selected from R15; or R5 is a 5- or 6-membered partially unsaturated heterocyclic ring which includes at least one heteroatom selected form N, O and S, the ring connected through a nitrogen atom or an sp2 carbon atom to the remainder of Formula (I) and optionally substituted by one or more substituents selected from R16; and R1a, R1b, R2a, R2b, R3, R4, R15, R16, T, U, W, Y and Z are as defined in the disclosure.

  公式（I）的化合物及其N-氧化物和农业适用盐已被披露，可用于控制不受欢迎的植被：其中（J）为（J-1）、（J-2）、（J-3）、（J-4）、（J-5）、（J-6）、（J-7）、（J-8）或（J-9）；R5为苯环或含有N、O和S中至少一个杂原子的5-或6-成员杂芳环，每个环可以选择性地取代一个或多个R15所选取的取代基；或者R5为包含至少一个N、O和S中选取的杂原子的5-或6-成员部分不饱和杂环，该环通过氮原子或sp2碳原子连接到公式（I）的其余部分，并可以选择性地取代一个或多个R16所选取的取代基；而R1a、R1b、R2a、R2b、R3、R4、R15、R16、T、U、W、Y和Z的定义如披露中所述。