6-Amino-4-(3-hydroxy-4-methoxyphenyl)-3-(4-methylphenyl)-1H,4H-pyrano[2,3-C]pyrazole-5-carbonitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 6-Amino-4-(3-hydroxy-4-methoxyphenyl)-3-(4-methylphenyl)-1H,4H-pyrano[2,3-C]pyrazole-5-carbonitrile
• 英文别名: 6-amino-4-(3-hydroxy-4-methoxyphenyl)-3-(4-methylphenyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile
• 化学式: C₂₁H₁₈N₄O₃
• 分子量: 374.4
• InChiKey: GWQXTIWNNNKJQN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  117
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• SIRT1 modulators for manipulating cell/organism lifespan/stress response
  申请人：President and Fellows of Harvard College

  公开号：EP2289504A2

  公开（公告）日：2011-03-02

  Provided herein are methods and compositions for modulating the activity of sirtuin deacetylase protein family members; p53 activity; apoptosis; lifespan and sensitivity to stress of cells and organisms. Exemplary methods comprise contacting a cell with an activating compound, such as a flavone, stilbene, flavanone, isoflavone, catechin, chalcone, tannin or anthocyanidin; or an inhibitory compound, such as a sphingolipid, e.g., sphingosine.

  本文提供了用于调节 sirtuin 去乙酰化酶家族成员活性、p53 活性、细胞凋亡、寿命以及细胞和生物体对应激的敏感性的方法和组合物。示例性方法包括使细胞与激活化合物接触，如黄酮、链烯、黄烷酮、异黄酮、儿茶素、查尔酮、单宁或花青素；或与抑制化合物接触，如鞘磷脂，如鞘磷脂。
• XENOHORMESIS BASED COMPOSITIONS AND METHODS
  申请人：Sinclair David A.

  公开号：US20100242139A1

  公开（公告）日：2010-09-23

  The present invention provides methods and compositions for improving the health of subjects, such as their resistance to stress.
• US7544497B2
  申请人：——

  公开号：US7544497B2

  公开（公告）日：2009-06-09
• US8017634B2
  申请人：——

  公开号：US8017634B2

  公开（公告）日：2011-09-13