5-[1-(1H-imidazol-5-yl)propan-2-ylamino]-5-oxopentanoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-[1-(1H-imidazol-5-yl)propan-2-ylamino]-5-oxopentanoic acid
• 化学式: C₁₁H₁₇N₃O₃
• 分子量: 239.27
• InChiKey: FEYIRYAWJRCKHX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  95.1
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• AMIDE COMPOUND AND USE THEREOF AS AGENT FOR THE TREATMENT AND PREVENTION OF DISEASES CAUSED BY RNA- AND/OR DNA-CONTAINING VIRUSES, AND CONCOMITANT DISEASES
  申请人：Obschestvo S Ogranichennoi Otvetstvennostiyu "Pharmenterprises"

  公开号：EP3431469A1

  公开（公告）日：2019-01-23

  The present invention relates to medicine and is concerned with a compound of formula (a) below or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising an effective amount of the compound of formula (a) or a pharmaceutically acceptable salt thereof; and kits comprising the pharmaceutical composition comprising an effective amount of the compound of formula (a) or a pharmaceutically acceptable salt thereof, pharmaceutically acceptable carriers and excipients, and instructions for use thereof; for use in preventing or treating diseases caused by RNA- and DNA-containing viruses, and concomitant diseases. The invention addresses the object of providing a compound for use in the prevention or treatment of diseases or complications of infectious diseases, whereby the diseases or infectious diseases are caused by an RNA-containing virus belonging to the Enterovirus, Metapneumovirus, Pneumovirus, Respirovirus, or Alfa-coronavirus genus, and/or by a DNA-containing virus belonging to the Adenoviridae and/or Herpesviridae family; for use in the prevention or treatment of asthma exacerbation, chronic obstructive pulmonary disease, mucoviscidosis, conjunctivitis, gastroenteritis, hepatitis, myocarditis; and for use in the prevention or treatment of rhinorrhea, acute and infectious rhinitis, pharyngitis, nasopharyngitis, tonsillitis, laryngitis, laryngotracheitis, laryngotracheobronchitis, bronchitis, bronchiolitis, pneumonia, or airway obstructive syndrome.

  本发明涉及医药，涉及以下式(a)化合物或其药学上可接受的盐；包含有效量式(a)化合物或其药学上可接受的盐的药物组合物；以及包含有效量式(a)化合物或其药学上可接受的盐、药学上可接受的载体和赋形剂的药物组合物及其使用说明的试剂盒；用于预防或治疗由含RNA和DNA病毒引起的疾病及并发症。 本发明的目的是提供一种用于预防或治疗疾病或传染性疾病并发症的化合物，其中疾病或传染性疾病是由属于肠道病毒属、偏肺病毒属、肺炎病毒属、呼吸道病毒属或阿法-冠状病毒属的含 RNA 病毒和/或属于腺病毒科和/或疱疹病毒科的含 DNA 病毒引起的；用于预防或治疗哮喘加重、慢性阻塞性肺病、粘液粘稠病、结膜炎、肠胃炎、肝炎、心肌炎；用于预防或治疗鼻炎、急性和传染性鼻炎、咽炎、鼻咽炎、扁桃体炎、喉炎、喉气管炎、喉气管支气管炎、支气管炎、支气管炎、肺炎或气道阻塞综合征。