7-氧代壬酸 | 20356-92-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 7-氧代壬酸
• 英文名称: 7-oxononanoic acid
• 英文别名: 7-Oxo-nonansaeure；7-Oxo-nonanoic acid
• CAS: 20356-92-7
• 化学式: C₉H₁₆O₃
• mdl: MFCD01320161
• 分子量: 172.224
• InChiKey: BMDUEIZQNLDNCI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.777
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2918300090

反应信息

• 作为反应物：
  描述：

  7-氧代壬酸 在 氢氧化钾 、 一水合肼 、 二乙二醇 作用下， 生成 壬酸
  参考文献：
  名称：

  Huenig et al., Chemische Berichte, 1958, vol. 91, p. 129,133

  摘要：

  DOI：
• 作为产物：
  描述：

  2-propionyl-hexanoic acid ethyl ester 生成 7-氧代壬酸
  参考文献：
  名称：

  Blaise; Koehler, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1909, vol. 148, p. 490

  摘要：

  DOI：

文献信息

• Heterocycle Derivatives As Histone Deacetylase (Hdac) Inhibitors
  申请人：Attenni Barbara

  公开号：US20090048228A1

  公开（公告）日：2009-02-19

  The present invention relates to compounds of formula I: or pharmaceutically acceptable salts or tautomers thereof, which are inhibitors of histone deacetylase (HDAC). The compounds of the present invention are useful for treating cellular proliferative diseases, including cancer. Further, the compounds of the present invention are useful for treating neurodegenerative diseases, schizophrenia and stroke among other diseases.

  本发明涉及以下式I的化合物：或其药用可接受的盐或互变异构体，这些化合物是组蛋白去乙酰化酶（HDAC）的抑制剂。本发明的化合物可用于治疗细胞增殖性疾病，包括癌症。此外，本发明的化合物还可用于治疗神经退行性疾病、精神分裂症和中风等其他疾病。
• [EN] HALOALKENE COMPOUNDS, PROCESS FOR THEIR PRODUCTION AND PESTICIDES CONTAINING THEM<br/>[FR] HALOALCENES, PROCEDE DE PRODUCTION D'HALOALCENES ET PESTICIDES CONTENANT CES HALOALCENES
  申请人：ISHIHARA SANGYO KAISHA

  公开号：WO2004052872A1

  公开（公告）日：2004-06-24

  ABSTRACT A novel haloalkene compound represented by the formula (I), useful as an active ingredient of a pesticide, is presented: wherein each of X1 and X2 is halogen, Y is a hydrogen atom, halogen, alkyl or the like, n is from 0 to 5, A is an oxygen atom or a sulfur atom, G is a hydrogen atom, alkyl, acyl or the like, and Q is a 5- to 12-membered heterocyclic group (the heterocyclic group may be substituted) containing an optional hetero atom selected from an oxygen atom, a sulfur atom and a nitrogen atom, alkyl which may be substituted by W, alkenyl which may be substituted by W, alkynyl which may be substituted by W, or cycloalkyl which may be substituted by W, wherein W is halogen, alkoxy, alkylthio, hydroxyl, cyano, nitro or phenyl which may be substituted.

  摘要：提供了一种新型卤烯化合物，其化学式表示为（I），可作为杀虫剂的活性成分：其中X1和X2中的每一个是卤素，Y是氢原子，卤素，烷基或类似物，n为0至5，A是氧原子或硫原子，G是氢原子，烷基，酰基或类似物，Q是一个含有5至12个成员的杂环基团（杂环基团可能被取代），其中可选地包含从氧原子、硫原子和氮原子中选择的一个杂原子，烷基可被W取代，烯基可被W取代，炔基可被W取代，或环烷基可被W取代，其中W是卤素，烷氧基，烷基硫基，羟基，氰基，硝基或可能被取代的苯基。
• [EN] HALOALKENE COMPOUNDS, PROCESS FOR THEIR PRODUCTION AND PESTICIDES CONTAINING THEM<br/>[FR] COMPOSES D'HALOALCENE, PROCEDE DE PRODUCTION ET PESTICIDES LES CONTENANT
  申请人：ISHIHARA SANGYO KAISHA

  公开号：WO2005063018A1

  公开（公告）日：2005-07-14

  Present invention relates to a haloalkene compound of the formula (I)or its salt: wherein each of X1 and X2 is halogen; Y is alkyl, haloalkyl or phenyl; n is 0 to 5; L is -C(=B)Q, -C(=B)B’Q, -C(=B)N(D)Q, -N(D)Q, -N(D)C(=B)Q, -N(D)C(=B)B’Q, -N(D)SO2Q, -N=CHQ, -N=C(Q)2, -SO2Q, -SO2N(D)Q or alkyl substituted by J, G is a hydrogen atom, alkyl, haloalkyl, phenylalkyl, alkenyl, haloalkenyl, phenylalkenyl, alkynyl, haloalkynyl, phenylalkynyl, -C(=B)Q, -C(=B)B’Q, -C(=B)N(G’)Q, -SQ, -SO2Q, -SN(G’)Q, -SN(G’)C(=B)B’Q or -SO2N(G’)Q; A is an oxygen atom or a sulfur atom.

  本发明涉及一种具有以下式(I)或其盐的卤烯化合物：其中X1和X2中的每一个都是卤素；Y是烷基、卤代烷基或苯基；n为0至5；L为-C(=B)Q、-C(=B)B’Q、-C(=B)N(D)Q、-N(D)Q、-N(D)C(=B)Q、-N(D)C(=B)B’Q、-N(D)SO2Q、-N=CHQ、-N=C(Q)2、-SO2Q、-SO2N(D)Q或被J取代的烷基；G是氢原子、烷基、卤代烷基、苯基烷基、烯基、卤代烯基、苯基烯基、炔基、卤代炔基、苯基炔基、-C(=B)Q、-C(=B)B’Q、-C(=B)N(G’)Q、-SQ、-SO2Q、-SN(G’)Q、-SN(G’)C(=B)B’Q或-SO2N(G’)Q；A是氧原子或硫原子。
• Alkaline Cleavage of Unsymmetrical β-Diketones. Ring Opening of Acylcylohexanones to Form ε-Acyl Caproic Acids¹
  作者：Charles R. Hauser、Frederic W. Swamer、Betty I. Ringler

  DOI：10.1021/ja01192a016

  日期：1948.12
• The influence of the lipophilicity of 7-oxoacyl-l-alanyl-d-isoglutamines on their immunorestoration activity in vivo
  作者：M Sollner、S Pečar、A Štalc

  DOI：10.1016/s0223-5234(97)89858-3

  日期：1996.1

  In search for immunologically active dipeptides, a series of new N-(7-oxoacyl)-L-alanyl-D-isoglutamines has been synthesized where lipophilicity was varied by changing the 7-oxoacyl residue from 7-oxooctanoyl to 7-oxotetradecanoyl. The immunological properties of the compounds were examined in an in vivo immunorestoration test. It was found that lipophilicity had a significant influence on the potency of the compounds tested. Compounds between N-(7-oxodecanoyl)-L-alanyl-D-isoglutamine and N-(7-oxotetradecanoyl)-L-alanyl-D-isoglutamine showed biphasic influence on efficacy. The most active compound found was 7-oxododecanoyl-L-alanyl-D-isoglutamine, which also has an activity comparable to that of azimexone.

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