potassium oleate | 17378-39-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: potassium oleate
• 英文别名: elaidic acid potassium salt；potassium elaidate；elaidic acid ; potassium elaidate；Elaidinsaeure; Kaliumelaidat；Elaidinsaeure; Kaliumsalz；potassium;(E)-octadec-9-enoate
• CAS: 17378-39-1
• 化学式: C₁₈H₃₃O₂*K
• 分子量: 320.557
• InChiKey: MLICVSDCCDDWMD-RRABGKBLSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  1.78
• 重原子数：
  21
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  40.1
• 氢给体数：
  0
• 氢受体数：
  2

ADMET

毒理性

• 相互作用

雌二醇、己烯雌酚和睾酮抑制了年轻大鼠和老年雌性大鼠肝脏匀浆中从甲羟戊酸生物合成自由和酯化胆固醇的过程。油酸钾倾向于减少性激素的抑制效果。

ESTRADIOL, DIETHYLSTILBESTROL, & TESTOSTERONE INHIBITED BIOSYNTHESIS OF FREE & ESTERIFIED CHOLESTEROL FROM MEVALONIC ACID IN LIVER HOMOGENATE PREPN FROM YOUNG RATS & OLD FEMALE RAT PREPN. POTASSIUM OLEATE TENDED TO DECR THE INHIBITORY EFFECT OF THE SEX HORMONES.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

吸尘会导致鼻和喉咙刺激、咳嗽和打喷嚏。摄入会导致口腔和胃部刺激。与眼睛接触会引起刺激。

INHALATION OF DUST CAUSES IRRITATION OF NOSE & THROAT, COUGHING, & SNEEZING. INGESTION CAUSES IRRITATION OF MOUTH & STOMACH. CONTACT WITH EYES CAUSES IRRITATION.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

使用兔眼刺激性试验（Draize眼试验），12%的油酸钾水溶液引起了相当的眼部刺激，与70%的异丙醇标准溶液相比。

USING THE RABBIT DRAIZE EYE TEST, POTASSIUM OLEATE (12% AQ) CAUSED CONSIDERABLE EYE IRRITATION COMPARED TO A 70% ISOPROPYL ALC STD.

来源:Hazardous Substances Data Bank (HSDB)

反应信息

• 作为反应物：
  描述：

  potassium oleate 、 溴甲苯 生成 (E)-9-octadecenoic acid benzyl ester
  参考文献：
  名称：

  SCHATOWITZ, BERT;GERCKEN, GUNTHER, J. CHROMATOGR., 409,(1987) 43-54

  摘要：

  DOI：
• 作为产物：
  描述：

  反油酸 在 potassium hydroxide 作用下， 以 甲醇 为溶剂， 生成 potassium oleate
  参考文献：
  名称：

  Interaction kinetics of liposome-incorporated unsaturated fatty acids with fatty acid-binding protein 3 by surface plasmon resonance

  摘要：

  The role of heart-type fatty acid-binding protein (FABP3) in human physiology as an intracellular carrier of fatty acids (FAs) has been well-documented. In this study, we aimed to develop an analytical method to study real-time interaction kinetics between FABP3 immobilized on the sensor surface and unsaturated C18 FAs using surface plasmon resonance (SPR). To establish the conditions for SPR experiments, we used an FABP3-selective inhibitor 4-(2-(1-(4-bromophenyl)-5-phenyl-1H-pyrazol-3-yl)-phenoxy)-butyric acid. The affinity index thus obtained was comparable to that reported previously, further supporting the usefulness of the SPR-based approach for evaluating interactions between FABPs and hydrophobic ligands. A pseudo-first-order affinity of FABP3 to K+ petroselinate (C18:1 Delta 61 cis), K+ elaidate (C18:1 Delta 9 trans), and K+ oleate (C18:1 Delta 9 cis) was characterized by the dissociation constant (K-d) near micromolar ranges, whereas K+ linoleate (C18:2 Delta 9,12 cis/cis) and K+ alpha-linolenate (C18:3 Delta 9,12,15 cis/cis/cis) showed a higher affinity to FABP3 with K-d around 1 x 10 (6) M. Interactions between FAPB3 and C18 FAs incorporated in large unilamellar vesicles consisting of 1,2-dimyristoyl-sn-glycero-3-phosphocholine and FAs (5:1 molar ratio) were also analysed. Control DMPC liposomes without FA showed only marginal binding to FABP3 immobilized on a sensor chip while liposome-incorporated FA revealed significant responses in sensorgrams, demonstrating that the affinity of FAs to FABP3 could be evaluated by using the liposome-incorporated analytes. Significant affinity to FABP3 was observed for monounsaturated fatty acids (K-d in the range of 1 x 10 (7) M). These experiments demonstrated that highly hydrophobic compounds in a liposome-incorporated form could be subjected to SPR experiments for kinetic analysis. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2014.02.001

文献信息

• Polyoxymethylene resin composition
  申请人：——

  公开号：US20020183430A1

  公开（公告）日：2002-12-05

  A polyoxymethylene resin composition, which comprises (A) 100 parts by weight of polyoxymethylene resin, (B) 0.01 to 5 parts by weight of at least one polymer selected from homopolymers of N-vinylcarboxylic acid amides and copolymers of N-vinylcarboxylic acid amides and other vinyl monomers, and (C) 0.01 to 5 parts by weight of at least one compound selected from the group consisting of polyalkylene glycol and its derivatives, fatty acid amides, esters of alcohols and fatty acids, and esters of alcohols and dicarboxylic acids. Such a polyoxymethylene resin composition has a small amount of released formaldehyde gas during production and molding and suppressed scorching generation and is also distinguished in the water resistance and repeated impact resistance of the resulting moldings.

  一种聚甲醛树脂组合物，它包括(A)100 份（按重量计）聚甲醛树脂，(B)0.01 至 5 份（按重量计）至少一种选自 N-乙烯基羧酸酰胺均聚物和 N-乙烯基羧酸酰胺与其他乙烯基单体共聚物的聚合物，以及(C)0.0.01 至 5 重量份的至少一种化合物，该化合物选自由聚亚烷基二醇及其衍生物、 脂肪酸酰胺、醇和脂肪酸的酯以及醇和二羧酸的酯组成的组。这样的聚甲醛树脂组合物在生产和成型过程中释放的甲醛气体量少，焦烧的产生受到抑制，所制成的成型品的耐水性和耐反复冲击性也很出色。
• MANOLOV I.; JOVTSCHEFF A. L., DOKL. BOLG. AN, 1977, 30, HO 7, 1025-
  作者：MANOLOV I.、 JOVTSCHEFF A. L.

  DOI：——

  日期：——
• SCHATOWITZ, BERT;GERCKEN, GUNTHER, J. CHROMATOGR., 409,(1987) 43-54
  作者：SCHATOWITZ, BERT、GERCKEN, GUNTHER

  DOI：——

  日期：——
• ——
  作者：GODREJ N. B.、 THAKUR M. S.

  DOI：——

  日期：——
• CLEANSING COMPOSITION
  申请人：Shiseido Company, Ltd.

  公开号：EP2251403B1

  公开（公告）日：2012-08-29