6,7-dimethoxy-3,3-dimethyl-1-(4-nitrophenyl)-4H-isoquinoline | 425400-78-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢异喹啉
• 英文名称: 6,7-dimethoxy-3,3-dimethyl-1-(4-nitrophenyl)-4H-isoquinoline
• CAS: 425400-78-8
• 化学式: C19H20N2O4
• 分子量: 340.4
• InChiKey: PRMPNZDTQSRKDY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  76.6
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• METHODS AND COMPOSITIONS FOR THE TREATMENT OF AMYLOIDOSIS
  申请人：Ultragenyx Pharmaceutical Inc.

  公开号：US20170119861A1

  公开（公告）日：2017-05-04

  Methods and compositions for the treatment or prevention of amyloidosis are provided. In some embodiments, the methods comprise administering to the subject a therapeutically effective amount of at least one catabolic enzyme or a biologically active fragment thereof. Such methods and compositions may be employed to reduce, prevent, degrade and/or eliminate amyloid formation in the lysosome and/or extracellularly.