US9862707, Example 41

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: US9862707, Example 41
• 英文别名: 2-fluoro-N-[6-(2-hydroxypropan-2-yl)-2-phenylpyrazolo[4,3-b]pyridin-3-yl]-5-(1-methylpyrazol-3-yl)-4-(trifluoromethyl)benzamide
• 化学式: C₂₇H₂₂F₄N₆O₂
• 分子量: 538.5
• InChiKey: HTXYHBDVEBYXEI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  39
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  97.9
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• TRKA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP3122344B1

  公开（公告）日：2022-04-27
• US9862707B2
  申请人：——

  公开号：US9862707B2

  公开（公告）日：2018-01-09
• [EN] TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF<br/>[FR] INHIBITEURS DE LA KINASE TRKA, COMPOSITIONS EN CONTENANT ET MÉTHODES ASSOCIÉES
  申请人：MERCK SHARP & DOHME

  公开号：WO2015148354A2

  公开（公告）日：2015-10-01

  The present invention is directed to a bicyclic heteroaryl benzamide compounds of formula (I) which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.