(5r)-N-(1-{2-[4-(2-Methoxyethyl)piperazin-1-Yl]ethyl}-1h-Pyrazol-3-Yl)-5,8-Dimethyl-9-Phenyl-6,8-Dihydro-5h-Pyrazolo[3,4-H]quinazolin-2-Amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (5r)-N-(1-{2-[4-(2-Methoxyethyl)piperazin-1-Yl]ethyl}-1h-Pyrazol-3-Yl)-5,8-Dimethyl-9-Phenyl-6,8-Dihydro-5h-Pyrazolo[3,4-H]quinazolin-2-Amine
• 英文别名: (5R)-N-[1-[2-[4-(2-methoxyethyl)piperazin-1-yl]ethyl]pyrazol-3-yl]-5,8-dimethyl-9-phenyl-5,6-dihydropyrazolo[3,4-h]quinazolin-2-amine
• 化学式: C₂₉H₃₇N₉O
• 分子量: 527.7
• InChiKey: PHQDLOFSIWRQJZ-OAQYLSRUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  39
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  89.2
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• [EN] NEW 5,8-DIMETHYL-9-PHENYL-5,8-DIHYDRO-6H-PYRAZOLO[3,4-H]QUINAZOLIN-2- YL)-(1 H-PYRAZOL-3-YL)-AMINES AND DERIVATIVES AS IGF-1 R/IR INHIBITORS<br/>[FR] NOUVEAUX 5,8-DIMÉTHYL-9-PHÉNYL-5,8-DIHYDRO-6H-PYRAZOLO[3,4-H]QUINAZOLIN-2- YL)-(1 H-PYRAZOL-3-YL)-AMINES ET DÉRIVÉS EN TANT QU'INHIBITEURS D'IGF-1R/IR
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2016180843A1

  公开（公告）日：2016-11-17

  The present invention encompasses compounds of formula (I) wherein the groups A, R and q are defined in claim 1, their use as inhibitors of IGF-1 R, pharmaceutical compositions which contain compounds of this kind and their use as medicaments, especially as agents for treatment and/or prevention of oncological diseases.

  本发明涵盖了式（I）中A、R和q基团的化合物，其中这些基团在权利要求书中有定义，它们作为IGF-1 R的抑制剂的用途，包含这类化合物的药物组合物以及它们作为药物的用途，特别是作为治疗和/或预防肿瘤疾病的药物。
• 5,8-dimethyl-9-phenyl-5,8-dihydro-6H-pyrazolo[3,4-h]quinazolin-2-yl)-(1H-pyrazol-3-yl)-amines as IGF-1R/IR inhibitors
  申请人：Boehringer Ingelheim International GmbH

  公开号：US10414769B2

  公开（公告）日：2019-09-17

  The present invention encompasses compounds of formula (I) wherein the groups A, R and q are defined in claim 1, their use as inhibitors of IGF-1R, pharmaceutical compositions which contain compounds of this kind and their use as medicaments, especially as agents for treatment and/or prevention of oncological diseases.

  本发明包括式 (I) 的化合物 其中基团 A、R 和 q 在权利要求 1 中定义；它们作为 IGF-1R 抑制剂的用途；含有此类化合物的药物组合物；以及它们作为药物，特别是作为治疗和/或预防肿瘤疾病的药物的用途。
• NEW 5,8-DIMETHYL-9-PHENYL-5,8-DIHYDRO-6H-PYRAZOLO[3,4-H]QUINAZOLIN-2-YL)-(1H-PYRAZOL-3-YL)-AMINES AND DERIVATIVES AS IGF-1R/IR INHIBITORS
  申请人：Boehringer Ingelheim International GmbH

  公开号：US20180141948A1

  公开（公告）日：2018-05-24

  The present invention encompasses compounds of formula (I) wherein the groups A, R and q are defined in claim 1 , their use as inhibitors of IGF-1 R, pharmaceutical compositions which contain compounds of this kind and their use as medicaments, especially as agents for treatment and/or prevention of oncological diseases.