4-(2,5-Diethylphenyl)-1,3-thiazol-2-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-(2,5-Diethylphenyl)-1,3-thiazol-2-amine
• 化学式: C₁₃H₁₆N₂S
• mdl: MFCD06655161
• 分子量: 232.35
• InChiKey: JAVGORYGBJIUAT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.307
• 拓扑面积：
  67.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Metabotropic glutamate receptor modulators
  申请人：Kalvinsh Ivars

  公开号：US20070299113A1

  公开（公告）日：2007-12-27

  The invention relates to imidazothiazole derivatives as well as their pharmaceutically acceptable salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are group I mGluR modulators and are therefore useful for the control and prevention of various disorders, including acute and/or chronic neurological disorders.

  该发明涉及咪唑硫唑衍生物及其药用可接受的盐。该发明还涉及一种制备此类化合物的方法。该发明的化合物是I类mGluR调节剂，因此对于控制和预防各种疾病，包括急性和/或慢性神经系统疾病，具有用处。
• [EN] ISOXAZOLIDINE COMPOUNDS FOR TREATMENT OF BACTERIAL INFECTIONS<br/>[FR] TRAITEMENT D'INFECTIONS BACTERIENNES AU MOYEN DE COMPOSES D'ISOXAZOLIDINE
  申请人：INFINITY PHARMACEUTICALS INC

  公开号：WO2006009907A2

  公开（公告）日：2006-01-26

  The present invention relates to antibiotic compounds and intermediates useful in their preparation. Many of the antibiotic compounds contain a substituted isoxazolidine ring. The invention also relates to pharmaceutical compositions containing a compound of the invention. The invention further provides processes for the preparation of compounds of the invention, and methods for their use as therapeutic agents.
• [EN] TETRAHYDRO-PYRANOPYRAZOLE COMPOUNDS DISPLAYING CANNABINOID MODULATING ACTIVITIES<br/>[FR] COMPOSES TETRAHYDRO-PYRANOPYRAZOLE PRESENTANT DES ACTIVITES DE MODULATION DE CANNABINOÏDE
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2007001939A1

  公开（公告）日：2007-01-04

  [EN] This invention is directed to a tetrahydro-pyranopyrazole cannabinoid modulator compound of formula (I): and a method for use in treating, ameliorating or preventing a cannabinoid receptor mediated syndrome, disorder or disease.
  [FR] La présente invention concerne un composé tétrahydro-pyranopyrazole modulateur de cannabinoïde de formule (I) : et une méthode d'utilisation pour le traitement, l'amélioration ou la prévention de pathologies, troubles ou syndromes médiés par le récepteur de cannabinoïde.
• [EN] METABOTROPIC GLUTAMATE RECEPTOR MODULATORS<br/>[FR] MODULATEURS DU RÉCEPTEUR MÉTABOTROPIQUE DU GLUTAMATE
  申请人：MERZ PHARMA GMBH & CO KGAA

  公开号：WO2007148113A1

  公开（公告）日：2007-12-27

  [EN] The invention relates to imidazothiazole derivatives as well as their pharmaceutically acceptable salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are group I mGluR modulators and are therefore useful for the control and prevention of various disorders, including acute and/or chronic neurological disorders.
  [FR] L'invention concerne des dérivés d'imidazothiazole ainsi que leurs sels pharmaceutiquement acceptables. L'invention concerne en outre un procédé destiné à la préparation de tels composés. Les composés selon l'invention sont des modulateurs de groupe I mGluR, et sont par conséquent utiles dans le contrôle et la prévention de divers troubles, y compris des troubles neurologiques aigus et/ou chroniques.