6-Methyl-3',4'-dimethoxy-flavanon | 105166-62-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 6-Methyl-3',4'-dimethoxy-flavanon
• 英文别名: 3',4'-Dimethoxy-6-methyl-flavanon；4h-1-Benzopyran-4-one,2-(3,4-dimethoxyphenyl)-2,3-dihydro-6-methyl-；2-(3,4-dimethoxyphenyl)-6-methyl-2,3-dihydrochromen-4-one
• CAS: 105166-62-9
• 化学式: C₁₈H₁₈O₄
• 分子量: 298.339
• InChiKey: WLCHVVPIRBNUHU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-Methyl-3',4'-dimethoxy-flavanon 生成 2,3-cis-3-Brom-3',4'-dimethoxy-6-methylflavanon
  参考文献：
  名称：

  REDDY N. J.; SHARMA T. C., BULL. CHEM. SOC. JAP., 1979, 52, NO 2, 647-648

  摘要：

  DOI：
• 作为产物：
  描述：

  (E)-2'-hydroxy-3,4-dimethoxy-5'-methylchalcone 生成 6-Methyl-3',4'-dimethoxy-flavanon
  参考文献：
  名称：

  SRIVASTAVA, Y. K.;VERMA, B. L., NAT. ACAD. SCI. LETT., 10,(1987) N 9, 319-321

  摘要：

  DOI：

文献信息

• Sharma, T. C.; Pawar, S. R.; Reddy, N. J., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1981, vol. 20, # 1, p. 80 - 81
  作者：Sharma, T. C.、Pawar, S. R.、Reddy, N. J.、Donnelly, John A.

  DOI：——

  日期：——
• Shivhare, Abha; Kale, Arun V.; Berge, Diwakar, D., Acta Chimica Hungarica, 1985, vol. 120, # 2, p. 107 - 110
  作者：Shivhare, Abha、Kale, Arun V.、Berge, Diwakar, D.

  DOI：——

  日期：——
• Synthesis and anticancer activity of a novel class of flavonoids: 2,4-Diarylchromane[4,3-d]-Δ1,9b-1,2,3-thiadiazolines
  作者：Huazhou Ying、Yongzhou Hu、Qiaojun He、Runping Li、Bo Yang

  DOI：10.1016/j.ejmech.2006.10.004

  日期：2007.2

  A series of 2,4-diarylchromane[4,3-d]-Delta(1.9b)-1,2,3-thiadiazolines have been synthesized by cyclization of corresponding 2-arylchroman-4-one-arylhydrazones with SOCl2 then treated with alcohol. All the compounds have been tested for their antiproliferative activity in vitro against six human tumor cell lines, and the highly potent derivative 11a exhibited in vivo inhibitory effect on tumor growth. Mechanism research indicated that it is due to 11a that induces DNA fragmentation. (c) 2006 Elsevier Masson SAS. All rights reserved.
• SHIVHARE, ABHA;KALE, ARUN, V., CHEM. AND IND., 1984, N 17, 633-634
  作者：SHIVHARE, ABHA、KALE, ARUN, V.

  DOI：——

  日期：——
• REICHEL L.; WEBER F. G., PHARMAZIE <PHAR-AT>, 1975, 30, NO 3, 195
  作者：REICHEL L.、 WEBER F. G.

  DOI：——

  日期：——