7-溴-3-庚炔 | 1028416-93-4

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机溴化物
• 中文名称: 7-溴-3-庚炔
• 英文名称: 7-Bromo-3-heptyne
• 英文别名: 4-Heptinylbromid；1-Bromo-4-heptyne；7-bromohept-3-yne
• CAS: 1028416-93-4
• 化学式: C₇H₁₁Br
• 分子量: 175.068
• InChiKey: GXFJTUGWFCWKDC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  7-溴-3-庚炔 在 Pd-BaSO₄ 喹啉 、 氢气 、 溶剂黄146 、 锌 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 60.0 ℃ 、101.33 kPa 条件下， 反应 2.63h， 生成 (2S,3R,6R)-(6E)-2-(3-Hydroxypropyl)-3-methyl-6-(4-heptenyl)piperidine
  参考文献：
  名称：

  Enantiogenic total syntheses of (-)-indolizidines (bicyclic gephyrotoxins) 205A, 207A, 209B, and 235B via the intramolecular Diels-Alder reaction of a chiral N-acylnitroso compound

  摘要：

  A general protocol for the enantiogenic total syntheses of a series of the 5-substituted 8-methylindolizidine class of alkaloids from the arrow poison frog, i.e., (-)-indolizidines 205A (1), 207A (2), 209B (3), and 235B (4), is described, in which a key step is the asymmetric intramolecular Diels-Alder reaction of the chiral N-acylnitroso compound 8 leading to the bicyclic oxazinolactam 7 which was utilized as a versatile common chiral intermediate for the preparation of these alkaloids. Subsequent introduction of the C-5 (in future) side chain was elaborated by means of a completely stereocontrolled process involving a Grignard reaction followed by reduction with NaBH4 in acidic media. The bicyclic oxazines 20a, 24, and 26 thus obtained were then subjected to reductive N-O bond cleavage followed by cyclodehydration using PPh3/CBr4/Et3N, which provided the (-)-enantiomers of the title alkaloids.

  DOI：

  10.1021/jo00036a024
• 作为产物：
  描述：

  1-丁炔 、 1,3-二溴丙烷 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 10.0h， 生成 7-溴-3-庚炔
  参考文献：
  名称：

  合成柠檬苦素的简单对映选择性方法

  摘要：

  一种对映选择性和短程合成柠檬苦素的方法已成功应用于最简单的柠檬苦素 2。四环骨架的碳原子在一次操作中由酰基硅烷 3 和炔砜 4 组装形成手性环氧化物 5。从 5 开始的连续阳离子和自由基环化产生了四环中间体 9a，通过以下序列将其转化为柠檬苦素 2，包括 (1) 环外双键的氧化裂解，(2) 立体选择性 α-甲基化，(3) 呋喃基附件，以及 (4) 引入 16-keto 功能。

  DOI：

  10.1021/ja802376g

文献信息

• ORGANIC INSULATING MATERIALS, VARNISHES FOR ORGANIC INSULATING FILM EMPLOYING THEM, ORGANIC INSULATING FILMS AND SEMICONDUCTOR DEVICES
  申请人：MATSUTANI Mihoko

  公开号：US20090318610A1

  公开（公告）日：2009-12-24

  There are provided organic insulating materials exhibiting low permittivity, high heat resistance and high mechanical strength, as well as organic insulating films with low permittivity, high heat resistance and high mechanical strength that employ the same, and semiconductor devices comprising the foregoing. An organic insulating material comprising a compound represented by general formula (1), or a polymer obtained by polymerizing a compound represented by general formula (1), or a mixture of a compound represented by general formula (1) and the polymer. X-VW n Y  (1) (In formula (1), X and Y each independently represent one or more groups with polymerizable functional groups. V and W each represent a group having an adamantane or polyamantane structure, and they may be the same or different. The letter n represents an integer of 0 or greater).

  提供了有机绝缘材料，具有低介电常数、高耐热性和高机械强度，以及采用相同材料的低介电常数、高耐热性和高机械强度的有机绝缘膜，以及包括上述材料的半导体器件。有机绝缘材料包括由通式（1）表示的化合物、由通式（1）表示的化合物聚合得到的聚合物，或通式（1）表示的化合物和聚合物的混合物。X和Y各自独立表示具有可聚合功能基团的一个或多个基团。V和W分别表示具有金刚烷或聚金刚烷结构的基团，它们可以相同也可以不同。字母n表示大于等于0的整数。
• SULFUR-CONTAINING PHOSPHOLIPID DERIVATIVES
  申请人：MILLER Andrew David

  公开号：US20120264966A1

  公开（公告）日：2012-10-18

  The present invention provides a lipid compound comprising at least one non-polar moiety and a polar moiety, wherein each or at least one non-polar moiety is of the formula X—Y—Z, wherein X is a hydrocarbyl chain, Y is selected from at least one of S, Se, SO 2 , SO, and O, and Z is an optional hydrocarbyl group, wherein the polar moiety is of the formula —[C(O)] m PHG, wherein PHG is a polar head group, and wherein m is the number of non-polar moieties.

  本发明提供了一种脂质化合物，其包括至少一个非极性基团和一个极性基团，其中每个或至少一个非极性基团的公式为X-Y-Z，其中X是一个烃基链，Y选择至少一个S、Se、SO2、SO和O，Z是一个可选的烃基团，极性基团的公式为-[C（O）]mPHG，其中PHG是极性头基团，m是非极性基团的数量。
• Preparation of cis-olefins
  申请人：NISSAN CHEMICAL INDUSTRIES LTD.

  公开号：EP0560532A1

  公开（公告）日：1993-09-15

  A method for preparing a cis-olefin of the formula : R1-CH=CH-R2 by reducing an alkyne of the formula: R1-C≡C-R2 with formic acid in the presence of a palladium catalyst. R1 and R2 are independently selected from the group consisting of a hydrogen atom, ester group, substituted silyl group, carboxyl group, cyano group, aliphatic CI-C20 hydrocarbon group, and phenyl group. The cis-olefin which is a useful intermediate for the synthesis of fine chemicals is selectively produced in high yields.

  一种制备式......的顺式烯烃的方法 R1-CH=CH-R2 的顺式烯烃的制备方法： R1-C≡C-R2 在钯催化剂存在下用甲酸还原。R1 和 R2 独立地选自氢原子、酯基、取代的硅烷基、羧基、氰基、脂肪族 CI-C20 烃基和苯基组成的组。这种顺式烯烃是合成精细化学品的有用中间体，可选择性地以高产率生产。
• ORGANIC INSULATING MATERIAL, VARNISH FOR ORGANIC INSULATING FILM USING THE SAME, ORGANIC INSULATING FILM AND SEMICONDUCTOR DEVICE
  申请人：Sumitomo Bakelite Co., Ltd.

  公开号：EP2117009A1

  公开（公告）日：2009-11-11

  There are provided organic insulating materials exhibiting low permittivity, high heat resistance and high mechanical strength, as well as organic insulating films with low permittivity, high heat resistance and high mechanical strength that employ the same, and semiconductor devices comprising the foregoing. An organic insulating material comprising a compound represented by general formula (1), or a polymer obtained by polymerizing a compound represented by general formula (1), or a mixture of a compound represented by general formula (1) and the polymer. (In formula (1), X and Y each independently represent one or more groups with polymerizable functional groups. V and W each represent a group having an adamantane or polyamantane structure, and they may be the same or different. The letter n represents an integer of 0 or greater.)

  本发明提供了具有低介电常数、高耐热性和高机械强度的有机绝缘材料，以及具有低介电常数、高耐热性和高机械强度的有机绝缘薄膜，以及包含上述材料的半导体器件。一种有机绝缘材料，包括通式（1）所代表的化合物，或通过聚合通式（1）所代表的化合物而得到的聚合物，或通式（1）所代表的化合物与聚合物的混合物。 式（1）中，X 和 Y 各自独立地代表一个或多个具有可聚合官能团的基团。V 和 W 各自代表具有金刚烷或聚金刚烷结构的基团，它们可以相同或不同。字母 n 代表 0 或更大的整数）。
• Seidel, Wolfgang; Schaefer, Hans J., Chemische Berichte, 1980, vol. 113, # 12, p. 3898 - 3903
  作者：Seidel, Wolfgang、Schaefer, Hans J.

  DOI：——

  日期：——