α-Benzoyl-glycinmethylester | 54011-34-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: α-Benzoyl-glycinmethylester
• 英文别名: 2-Amino-3-oxo-3-phenylpropionic acid methylester；methyl 2-amino-3-oxo-3-phenylpropanoate
• CAS: 54011-34-6
• 化学式: C₁₀H₁₁NO₃
• 分子量: 193.202
• InChiKey: WVRQHSWSAXRQGK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  69.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  α-Benzoyl-glycinmethylester 在 bis(η3-allyl-μ-chloropalladium(II)) 苯磺酰胺 、 potassium chloride 、 三乙胺 作用下， 以 甲苯 为溶剂， 反应 99.0h， 生成 methyl (E,2R)-2-acetamido-2-benzoyl-5-phenylpent-4-enoate
  参考文献：
  名称：

  Pd-catalyzed enantioselective synthesis of quaternary α-amino acid derivatives using a phenylalanine-derived P-chirogenic diaminophosphine oxide

  摘要：

  A Pd-catalyzed enantio selective synthesis of quaternary alpha-amino acid derivatives using a phenylalanine-derived P-chirogenic diaminophosphine oxide is described. Asymmetric allylic substitution using acyclic beta-keto esters with a nitrogen functional group at the alpha-carbon as prochiral nucleophiles proceeded in the presence of 5 mol % of Pd catalyst, 10 mol % of chiral diaminophosphine oxide 1j, BSA, and appropriate additives, affording the corresponding quaternary alpha-amino acid derivatives in excellent yield and in up to 92% ee. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.07.020
• 作为产物：
  描述：

  methyl 2-((tert-butoxycarbonyl)amino)-3-oxo-3-phenylpropanoate 在 盐酸 作用下， 以 1,4-二氧六环 为溶剂， 生成 α-Benzoyl-glycinmethylester
  参考文献：
  名称：

  Pd-catalyzed enantioselective synthesis of quaternary α-amino acid derivatives using a phenylalanine-derived P-chirogenic diaminophosphine oxide

  摘要：

  A Pd-catalyzed enantio selective synthesis of quaternary alpha-amino acid derivatives using a phenylalanine-derived P-chirogenic diaminophosphine oxide is described. Asymmetric allylic substitution using acyclic beta-keto esters with a nitrogen functional group at the alpha-carbon as prochiral nucleophiles proceeded in the presence of 5 mol % of Pd catalyst, 10 mol % of chiral diaminophosphine oxide 1j, BSA, and appropriate additives, affording the corresponding quaternary alpha-amino acid derivatives in excellent yield and in up to 92% ee. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.07.020

文献信息

• Compounds with growth hormone releasing properties
  申请人：Novo Nordisk A/S

  公开号：US06350767B1

  公开（公告）日：2002-02-26

  The present invention relates to compounds, compositions containing them, and their use for treating medical disorders resulting from a deficiency in growth hormone.

  本发明涉及化合物、含有这些化合物的组合物，以及它们用于治疗由生长激素缺乏引起的医学疾病的用途。
• FARNESYL TRANSFERASE INHIBITORS
  申请人：——

  公开号：US20020013319A1

  公开（公告）日：2002-01-31

  A family of compounds capable of inhibiting the activity of farnesyl transferase.

  一类能够抑制法尼醇转移酶活性的化合物家族。
• OXAZOLE OREXIN RECEPTOR ANTAGONISTS
  申请人：MERCK SHARP & DOHME CORP.

  公开号：US20160176858A1

  公开（公告）日：2016-06-23

  The present invention is directed to oxazole compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the oxazole compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

  本发明涉及噁唑化合物，其是促进睡眠的荷尔蒙受体的拮抗剂。本发明还涉及这些噁唑化合物在潜在的神经和精神障碍和疾病的治疗或预防中的应用，其中涉及到促进睡眠的荷尔蒙受体。本发明还涉及包含这些化合物的制药组合物。本发明还涉及这些制药组合物在预防或治疗涉及促进睡眠的荷尔蒙受体的疾病中的应用。
• Benzamides as ppar modulators
  申请人：Fernandez Serrat Anna

  公开号：US20060160894A1

  公开（公告）日：2006-07-20

  Compounds of general structure (I), wherein the central benzene ring may be substituted in the meta- or para-position; -A is an optionally substituted hydroxyl, alkoxyl, hydroxylamine, alkoxylamine or amine radical; -W is an N- and C-linked biradical selected from several possibilities; and -Z is a carbon radical selected from several possibilities. These compounds are PPARγ and PPARγ/PPARδ modulators and, therefore, are useful for the prophylactic and/or curative treatment of a condition or a disease mediated by these recetpcors.

  一般结构(I)的化合物，其中中心苯环可在元位或对位被取代；-A 是任选取代的羟基、烷氧基、羟胺、烷氧基胺或胺基；-W 是选自几种可能性的 N-和 C-连二自由基；-Z 是选自几种可能性的碳基。这些化合物是 PPARγ 和 PPARγ/PPARδ 调节剂，因此可用于预防和/或治疗由这些调节剂介导的病症或疾病。
• Synthesis of amino acids and related compounds. 6. New convenient synthesis of .alpha.-C-acylamino acids and .alpha.-amino ketones
  作者：Mamoru Suzuki、Tameo Iwasaki、Muneji Miyoshi、Kentaro Okumura、Kazuo Matsumoto

  DOI：10.1021/jo00960a028

  日期：1973.10