N-[2-[bis[2-(2-methylpropanoylamino)ethyl]amino]ethyl]-2-methylpropanamide | 1372722-40-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-[2-[bis[2-(2-methylpropanoylamino)ethyl]amino]ethyl]-2-methylpropanamide
• CAS: 1372722-40-1
• 化学式: C₁₈H₃₆N₄O₃
• 分子量: 356.509
• InChiKey: BBYRKEWRZZFKCH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  25
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  90.5
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  异戊酸酐 、 三(2-氨基乙基)胺 在 碳酸氢钠 作用下， 以 甲醇 为溶剂， 生成 N-[2-[bis[2-(2-methylpropanoylamino)ethyl]amino]ethyl]-2-methylpropanamide
  参考文献：
  名称：

  Novel lower critical solution temperature phase transition materials effectively control osmosis by mild temperature changes

  摘要：

  基于具有LCST转变的新型温度敏感性溶质，渗透作用可以通过温和的温度变化被可逆且有效地控制。nBu-TAEA温度敏感性溶液能够在低于相分离温度的情况下从海水中汲取淡水，并且在较高温度下会发生渗透流动的逆转。

  DOI：

  10.1039/c2cc30890h

文献信息

• Chain transfer agents for raft polymerization in aqueous media
  申请人：McCormick L. Charles

  公开号：US20070123670A1

  公开（公告）日：2007-05-31

  Polymers and copolymers synthesized by means that yield a narrow range of molecular weights can have different properties than polymers synthesized by conventional means. In order to obtain such polymers, however, polymerization must be controlled. One type of controlled polymerization is the reversible addition-fragmentation chain transfer (RAFT) process, which has characteristics of a living polymerization. The present invention discloses a group of dithioesters and trithioesters suitable as chain transfer agents for RAFT polymerization. The present invention also discloses RAFT polymerizations conducted in aqueous media.

  通过产生分子量窄范围的手段合成的聚合物和共聚物可能具有不同于传统手段合成的聚合物的性质。然而，为了获得这种聚合物，聚合必须受到控制。一种受控聚合的类型是可逆加成-断裂链转移（RAFT）过程，具有活性聚合的特征。本发明揭示了一组二硫代酯和三硫代酯，适用于RAFT聚合的链转移剂。本发明还揭示了在水介质中进行的RAFT聚合。
• MACROCYCLES
  申请人：Lumiphore, Inc.

  公开号：EP3129350B1

  公开（公告）日：2021-10-27
• MACROCYCLE CONJUGATES
  申请人：LUMIPHORE, INC.

  公开号：US20210290787A1

  公开（公告）日：2021-09-23

  The invention relates to chemical compounds and complexes that can be used in therapeutic and diagnostic applications. In various embodiments, the invention described herein pertains to the diagnosis, imaging, and/or treatment of pathogenic cell populations. In particular, the invention described herein pertains to the diagnosis, imaging, and/or treatment of diseases caused by PSMA express-ing cells, such as prostate cancer cells, using compounds capable of targeting PSMA expressing cells.
• US7402690B2
  申请人：——

  公开号：US7402690B2

  公开（公告）日：2008-07-22
• [EN] MACROCYCLES<br/>[FR] MACROCYCLES
  申请人：UNIV CALIFORNIA

  公开号：WO2013187971A2

  公开（公告）日：2013-12-19

  The invention provides macrocycles useful in chelating metal ions, particularly radionuclides, to provide metal ion complexes. The invention also provides methods of using the compounds and complexes of the invention, such as in therapeutic and diagnostic applications.