Methyl 4-amino-3-(2,4-difluorophenyl)-2-sulfanylidene-1,3-thiazole-5-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: Methyl 4-amino-3-(2,4-difluorophenyl)-2-sulfanylidene-1,3-thiazole-5-carboxylate
• 化学式: C₁₁H₈F₂N₂O₂S₂
• 分子量: 302.3
• InChiKey: VYPHYPFZPWGGDT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  113
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• INHIBITORS OF CRL4 UBIQUITIN LIGASE AND USES THEREOF
  申请人：Cornell University

  公开号：US20150196546A1

  公开（公告）日：2015-07-16

  The invention is directed to a method of treating a cancer in an animal and a method of increasing DNA repair activity in an animal. The methods comprise administering to an animal in need thereof an effective amount of a small molecule substance that interferes with the activity of CUL4A, such as a 1,3-benzoxathiol-2-one compound, a pyridine thione compound, a 2,6-diamino-4-thiopyran-3,5-dicarbonitrile compound, or a 1,2,4-triazole-3-thiol compound.

  本发明涉及一种治疗动物癌症和增加动物DNA修复活性的方法。该方法包括向需要治疗的动物中投与有效量的干扰CUL4A活性的小分子物质，比如1,3-苯并噻吩-2-酮化合物、吡啶硫酮化合物、2,6-二氨基-4-硫代吡喃-3,5-二氰基化合物或1,2,4-三唑-3-硫醇化合物。
• Inhibitors of CRL4 ubiquitin ligase and uses thereof
  申请人：Cornell University

  公开号：US10617683B2

  公开（公告）日：2020-04-14

  The invention is directed to a method of treating a cancer in an animal and a method of increasing DNA repair activity in an animal. The methods comprise administering to an animal in need thereof an effective amount of a small molecule substance that interferes with the activity of CUL4A, such as a 1,3-benzoxathiol-2-one compound, a pyridine thione compound, a 2,6-diamino-4-thiopyran-3,5-dicarbonitrile compound, or a 1,2,4-triazole-3-thiol compound.

  本发明涉及一种治疗动物癌症的方法和一种提高动物 DNA 修复活性的方法。这些方法包括向有需要的动物施用有效量的干扰CUL4A活性的小分子物质，如1,3-苯并氧硫醇-2-酮化合物、吡啶硫酮化合物、2,6-二氨基-4-噻喃-3,5-二甲腈化合物或1,2,4-三唑-3-硫醇化合物。
• [EN] INHIBITORS OF CRL4 UBIQUITIN LIGASE AND USES THEREOF<br/>[FR] INHIBITEURS DE L'UBIQUITINE-LIGASE CRL4 ET SES UTILISATIONS
  申请人：UNIV CORNELL

  公开号：WO2014031759A2

  公开（公告）日：2014-02-27

  The invention is directed to a method of treating a cancer in an animal and a method of increasing DNA repair activity in an animal. The methods comprise administering to an animal in need thereof an effective amount of a small molecule substance that interferes with the activity of CUL4A, such as a 1,3-benzoxathiol-2-one compound, a pyridine thione compound, a 2,6-diamino-4-thiopyran-3,5-dicarbonitrile compound, or a 1,2,4-triazole-3-thiol compound.