Isopentylmalonsaeure-dimethylester | 81144-15-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Isopentylmalonsaeure-dimethylester
• 英文别名: dimethyl 2-isopentylmalonate；Dimethyl isoamylmalonate；dimethyl 2-(3-methylbutyl)propanedioate
• CAS: 81144-15-2
• 化学式: C₁₀H₁₈O₄
• 分子量: 202.251
• InChiKey: RXGYCQDGQRZWLK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.38
• 重原子数：
  14.0
• 可旋转键数：
  5.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  52.6
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  3-Chlor-4-phenylcyclobutendion 、 Isopentylmalonsaeure-dimethylester 在 sodium 作用下， 生成 (3,4-Dioxo-2-phenylcyclobut-1-enyl)(isopentyl)malonsaeure-dimethylester
  参考文献：
  名称：

  Ried, Walter; Vogl, Manfred, Liebigs Annalen der Chemie, 1982, # 2, p. 355 - 359

  摘要：

  DOI：
• 作为产物：
  描述：

  3-甲基丁亚基丙二酸二甲酯 在 溶剂黄146 、 锌 作用下， 以 甲醇 、 甲苯 为溶剂， 反应 8.0h， 以5.98 g的产率得到Isopentylmalonsaeure-dimethylester
  参考文献：
  名称：

  Zn-AcOH体系的还原性Knoevenagel冷凝

  摘要：

  摘要 从可商购的醛和活性亚甲基化合物开始，开发了一种有效的克级一锅法制备2-取代的丙二酸酯和相关结构。该技术结合了Knoevenagel缩合与Zn-AcOH系统中所得活化烯烃中C = C键的还原。发生C ＝ C键还原的相对容易性可以追溯到中间亚芳基丙二酸酯中取代基的接受能力。 出版历史 收到：2020年5月21日 修订后接受：2020年9月16日 发布日期： 2020年10月29日（在线） ©2020年。Thieme。版权所有 Georg Thieme Verlag KGRüdigerstraße14，70469斯图加特，德国

  DOI：

  10.1055/s-0040-1705940

文献信息

• Prostaglandins E and anti ulcers containing same
  申请人：Kabushiki Kaisha Ueno Seiyaku Kenkyujo

  公开号：US05886034A1

  公开（公告）日：1999-03-23

  The novel 13,14-dihydro-15-keto prostaglandins E of the invention have remarkable preventive effects against ulcers. Further, the novel 13,14-dihydro-15-keto-prostaglandins E of the invention have an advatage that they have none of side effects which prostaglandin E intrinsically has, or can remarakably reduce such effects of the prostaglandin E. Therefore, the novel 13, 14-dihydro-15-keto prostaglandins E of the invention are effective for animal and human use for treatment and prevention of ulcers, such as duodenal ulcer and gastric ulcer.

  本发明的新型13,14-二氢-15-酮前列腺素E具有显著的溃疡预防效果。此外，本发明的新型13,14-二氢-15-酮前列腺素E具有优点，即它们没有前列腺素E所固有的副作用，或者可以显著减少前列腺素E的这些副作用。因此，本发明的新型13,14-二氢-15-酮前列腺素E对于治疗和预防溃疡，如十二指肠溃疡和胃溃疡，在动物和人类使用中是有效的。
• METHOD FOR PRODUCING SOLID CATALYST COMPONENT FOR USE IN POLYMERIZATION OF OLEFIN, CATALYST FOR USE IN POLYMERIZATION OF OLEFIN, AND METHOD FOR PRODUCING OLEFIN POLYMER
  申请人：Toho Titanium CO., LTD.

  公开号：EP2876118A1

  公开（公告）日：2015-05-27

  A method for producing a solid catalyst component for olefin polymerization produces a novel solid catalyst component for olefin polymerization that achieves excellent olefin polymerization activity and activity with respect to hydrogen during polymerization, and can produce an olefin polymer that exhibits a high MFR, high stereoregularity, and excellent rigidity. The method includes a first step that brings a magnesium compound, a tetravalent titanium halide compound, and one or more first internal electron donor compounds selected from specific aromatic dicarboxylic diesters into contact with each other to effect a reaction, followed by washing, a second step that brings a tetravalent titanium halide compound and one or more second internal electron donor compounds into contact with a product obtained by the first step to effect a reaction, followed by washing, and a third step that brings one or more third internal electron donor compounds into contact with a product obtained by the second step to effect a reaction.

  一种生产烯烃聚合用固体催化剂组分的方法可生产出一种新型的烯烃聚合用固体催化剂组分，该组分具有优异的烯烃聚合活性和聚合过程中对氢的活性，并可生产出具有高MFR、高立体规整度和优异刚性的烯烃聚合物。该方法包括第一步，使镁化合物、四价卤化钛化合物和一种或多种选自特定芳香族二羧酸二酯的第一内部电子供体化合物相互接触以发生反应，然后进行洗涤、第二步：使四价卤化钛化合物和一种或多种第二内部电子供体化合物与第一步得到的产物接触，以发生反应，然后进行洗涤；第三步：使一种或多种第三内部电子供体化合物与第二步得到的产物接触，以发生反应。
• PRODUCTION METHOD FOR SOLID CATALYST COMPONENT FOR POLYMERIZING OLEFINS, CATALYST FOR POLYMERIZING OLEFINS, AND PRODUCTION METHOD FOR POLYMERIZED OLEFINS
  申请人：TOHO TITANIUM CO., LTD.

  公开号：EP2963063A1

  公开（公告）日：2016-01-06

  A method for producing a solid catalyst component for olefin polymerization produces a novel solid catalyst component for olefin polymerization that achieves excellent olefin polymerization activity and activity with respect to hydrogen during polymerization, and can produce an olefin polymer that exhibits a high MFR, high stereoregularity, and excellent rigidity. The method includes a first step that brings a magnesium compound, a tetravalent titanium halide compound, and one or more first internal electron donor compounds excluding an aromatic dicarboxylic acid diester into contact with each other to effect a reaction, followed by washing; a second step that brings a tetravalent titanium halide compound and one or more second internal electron donor compounds into contact with a product obtained by the first step to effect a reaction, followed by washing; and a third step that brings one or more third internal electron donor compounds into contact with a product obtained by the second step to effect a reaction.

  一种生产烯烃聚合用固体催化剂组分的方法可生产出一种新型的烯烃聚合用固体催化剂组分，该组分具有优异的烯烃聚合活性和聚合过程中对氢的活性，并可生产出具有高MFR、高立体规整度和优异刚性的烯烃聚合物。该方法包括第一步，使镁化合物、四价卤化钛化合物和一种或多种第一内部电子供体化合物（不包括芳香族二羧酸二酯）相互接触以发生反应，然后进行洗涤；第二步，使四价卤化钛化合物和一种或多种第二内部电子供体化合物与第一步得到的产物接触，以发生反应，然后进行洗涤；以及第三步，使一种或多种第三内部电子供体化合物与第二步得到的产物接触，以发生反应。
• Method for producing solid catalyst component for olefin polymerization, catalyst for olefin polymerization, and method for producing olefin polymer
  申请人：Uozumi Toshiya

  公开号：US10364304B2

  公开（公告）日：2019-07-30

  A method for producing a solid catalyst component for olefin polymerization includes bringing a magnesium compound, a tetravalent titanium halide compound, and an electron donor compound represented by a general formula (1) into contact with each other, reacting the mixture, washing the resulting reaction product to obtain a solid component, bringing the solid component, a tetravalent titanium halide compound, and an electron donor compound represented by a general formula (2) into contact with each other, reacting the mixture, and washing the resulting reaction product. (R1)kC6H4-k(COOR2)(COOR3)  (1) R4R5C(COOR6)2  (2) A polymer that exhibits high activity with respect to hydrogen, high stereoregularity, and high bulk density can be obtained using a catalyst including a solid catalyst component obtained by the method.

  一种生产烯烃聚合用固体催化剂组分的方法，包括将镁化合物、四价卤化钛化合物和通式（1）表示的电子供体化合物相互接触，使混合物反应，洗涤所得反应产物以获得固体组分，将固体组分、四价卤化钛化合物和通式（2）表示的电子供体化合物相互接触，使混合物反应，洗涤所得反应产物。 (R1)kC6H4-k(COOR2)(COOR3) (1) R4R5C(COOR6)2 (2) 使用包括通过该方法获得的固体催化剂组分的催化剂，可以获得对氢具有高活性、高立体规整度和高体积密度的聚合物。
• Phosphoramidites Are Efficient, Green Organocatalysts for the Michael Reaction. Mechanistic Insights into the Phosphorus-Catalyzed Michael Reaction of Alkynones and Implications for Asymmetric Catalysis
  作者：Robert B. Grossman、Sébastien Comesse、Ravindra M. Rasne、Kazuyuki Hattori、Matthew N. Delong

  DOI：10.1021/jo026425g

  日期：2003.2.1

  Hexamethylphosphorous triamide (HMPT) and other phosphoramidites and phosphites have been found to be efficient catalysts for the Michael reaction of alkenones and alkynones with malonates, (x-cyano, esters, beta-keto esters, and nitro compounds. The relatively nontoxic, easily hydrolyzed HMPT catalyzes the Michael reaction within seconds at room temperature in the absence of a solvent, and the reaction is worked up simply by removing the catalyst in vacuo. The Michael reactions of alkynones, unlike those of alkenones, are shown to be irreversible. The implications for asymmetric catalysis are discussed.