3-[{2-[2-(2-tert-Butoxycarbonylamino-ethoxy)-ethoxy]-ethyl}-(2-methoxycarbonyl-ethyl)-amino]-propionic acid methyl ester | 918164-81-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-[{2-[2-(2-tert-Butoxycarbonylamino-ethoxy)-ethoxy]-ethyl}-(2-methoxycarbonyl-ethyl)-amino]-propionic acid methyl ester
• 英文别名: Methyl 3-[(3-methoxy-3-oxopropyl)-[2-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]ethoxy]ethyl]amino]propanoate
• CAS: 918164-81-5
• 化学式: C₁₉H₃₆N₂O₈
• 分子量: 420.503
• InChiKey: AKVSNGRAWGHJHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  29
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.84
• 拓扑面积：
  113
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  3-[{2-[2-(2-tert-Butoxycarbonylamino-ethoxy)-ethoxy]-ethyl}-(2-methoxycarbonyl-ethyl)-amino]-propionic acid methyl ester 、 乙二胺 、 丙烯酸甲酯（MA） 以 甲醇 为溶剂， 反应 144.0h， 以57%的产率得到3-[{2-[3-((2-{2-[Bis-(2-methoxycarbonyl-ethyl)-amino]-ethylcarbamoyl}-ethyl)-{2-[2-(2-tert-butoxycarbonylamino-ethoxy)-ethoxy]-ethyl}-amino)-propionylamino]-ethyl}-(2-methoxycarbonyl-ethyl)-amino]-propionic acid methyl ester
  参考文献：
  名称：

  Divergent synthesis of novel unsymmetrical dendrons containing photosensitizing units

  摘要：

  The synthesis, characterization and singlet oxygen quantum yield of novel unsymmetrical dendrons containing photosensitizing units at their periphery is reported. Boc-protected 2,2'-(ethylenedioxy)-bis-ethylamine reacted with methyl acrylate and ethylene diamine to give half-dendrimers 4 and 5 with 2 and 4 end groups, respectively. Amine-tethered porphyrins and compounds 4 and 5 were efficiently coupled in DMF at 100 degrees C to give the functionalized dendrons. UV-visible and fluorescence emission spectra showed that the photophysical properties of the porphyrins were retained in the dendrimers. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.10.005
• 作为产物：
  描述：

  丙烯酸甲酯（MA） 、 2-(2-(2-氨基乙氧基)乙氧基)乙基氨基甲酸叔丁酯 以 甲醇 为溶剂， 反应 24.0h， 以63%的产率得到3-[{2-[2-(2-tert-Butoxycarbonylamino-ethoxy)-ethoxy]-ethyl}-(2-methoxycarbonyl-ethyl)-amino]-propionic acid methyl ester
  参考文献：
  名称：

  Divergent synthesis of novel unsymmetrical dendrons containing photosensitizing units

  摘要：

  The synthesis, characterization and singlet oxygen quantum yield of novel unsymmetrical dendrons containing photosensitizing units at their periphery is reported. Boc-protected 2,2'-(ethylenedioxy)-bis-ethylamine reacted with methyl acrylate and ethylene diamine to give half-dendrimers 4 and 5 with 2 and 4 end groups, respectively. Amine-tethered porphyrins and compounds 4 and 5 were efficiently coupled in DMF at 100 degrees C to give the functionalized dendrons. UV-visible and fluorescence emission spectra showed that the photophysical properties of the porphyrins were retained in the dendrimers. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.10.005

文献信息

• Divergent synthesis of novel unsymmetrical dendrons containing photosensitizing units
  作者：Vincent Morosini、Céline Frochot、Muriel Barberi-Heyob、Raphaël Schneider

  DOI：10.1016/j.tetlet.2006.10.005

  日期：2006.12

  The synthesis, characterization and singlet oxygen quantum yield of novel unsymmetrical dendrons containing photosensitizing units at their periphery is reported. Boc-protected 2,2'-(ethylenedioxy)-bis-ethylamine reacted with methyl acrylate and ethylene diamine to give half-dendrimers 4 and 5 with 2 and 4 end groups, respectively. Amine-tethered porphyrins and compounds 4 and 5 were efficiently coupled in DMF at 100 degrees C to give the functionalized dendrons. UV-visible and fluorescence emission spectra showed that the photophysical properties of the porphyrins were retained in the dendrimers. (c) 2006 Elsevier Ltd. All rights reserved.