6-(2-imidazolin-2-yl)-2-[4-(2-imidazolin-2-yl)phenyl]indole | 64431-93-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 6-(2-imidazolin-2-yl)-2-[4-(2-imidazolin-2-yl)phenyl]indole
• 英文别名: 6-(4,5-Dihydro-1H-imidazol-2-yl)-2-[4-(4,5-dihydro-1H-imidazol-2-yl)-phenyl]-1H-indole；DIPI；2-[4-(2-imidazolinyl)phenyl]-6-(2-imidazolinyl)indole；6-(4,5-Dihydro-1H-imidazol-2-yl)-2-(4-(4,5-dihydro-1H-imidazol-2-yl)phenyl)-1H-indole；6-(4,5-dihydro-1H-imidazol-2-yl)-2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-1H-indole
• CAS: 64431-93-2
• 化学式: C₂₀H₁₉N₅
• 分子量: 329.404
• InChiKey: DOETVZCFKJCYJV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  64.6
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  tert-butyl 6-cyano-2-(4-cyanophenyl)-1H-indole-1-carboxylate 、 乙二胺 在 tetraphosphorus decasulfide 作用下， 反应 2.0h， 以74%的产率得到6-(2-imidazolin-2-yl)-2-[4-(2-imidazolin-2-yl)phenyl]indole
  参考文献：
  名称：

  Synthesis and Biological Evaluation of Botulinum Neurotoxin A Protease Inhibitors

  摘要：

  NSC 240898 was previously identified as a botulinum neurotoxin A light chain (BoNT/A LC) endopeptidase inhibitor by screening the National Cancer Institute Open Repository diversity set. Two types of analogues have been synthesized and shown to inhibit BoNT/A LC in a FRET-based enzyme assay, with confirmation in an HPLC-based assay. These two series of compounds have also been evaluated for inhibition of anthrax lethal factor (LF), an unrelated metalloprotease, to examine enzyme specificity of the BoNT/A LC inhibition. The most potent inhibitor against BoNT/A LC in these two series is compound 12 (IC50 = 2.5 mu M, FRET assay), which is 4.4-fold more potent than the lead structure and 11.2-fold more selective for BoNT/A LC versus the anthrax LF metalloproteinase. Structure-activity relationship studies have revealed structural features important to potency and enzyme specificity.

  DOI：

  10.1021/jm901852f

文献信息

• HIGH SPECIFICITY ANTICANCER PHARMACOLOGICAL DRUG SYSTEM, DRUG SYNTHESIS, AND DRUG DEVELOPMENT PROCESS
  申请人：——

  公开号：US20040116508A1

  公开（公告）日：2004-06-17

  A process for producing new anticancer drugs such that the drugs can be administered in a nontoxic, proto-drug form and, subsequent to a time delay which allows for differential concentration in the target cancer or invasive tissues or cells, the non-toxic drug is then modified by an activation drug to selectively provide toxic levels of a pharmacologically active agent to the target issue.

  一种生产新的抗癌药物的过程，使得这些药物可以以无毒的原药形式给予，并在经过一段时间延迟后，允许在目标癌症或侵袭性组织或细胞中产生差异浓度，然后通过激活药物修改非毒性药物，以选择性地提供目标组织的药理活性剂的毒性水平。
• High specificity anticancer drug design process
  申请人：——

  公开号：US20040192578A1

  公开（公告）日：2004-09-30

  A process for producing new anticancer drugs such that the drugs can be administered in a nontoxic, proto-drug form and, subsequent to a time delay which allows for differential concentration in the targer cancer or invasive tissues or cells, the non-toxic drug is then modified by an activation drug to selectively provide toxic levels of a pharmacologically active agent to the target issue.

  一种生产新型抗癌药物的方法，使药物可以以无毒的原型药物形式给予，并在延迟一段时间后，允许在目标癌细胞或侵入性组织或细胞中出现差异浓度，然后通过激活药物修改无毒药物，以选择性地向目标组织提供药理活性成分的毒性水平。
• METHOD OF COUNTING LEUKOCYTES AND LEUKOCYTE COUNTER
  申请人：KOWA COMPANY LTD.

  公开号：EP1031834A1

  公开（公告）日：2000-08-30

  A leukocyte counting method which comprises adding a cytolytic agent to a platelet preparation solution or an erythrocyte preparation solution to solubilize the platelets or erythrocytes in the respective solution in a leukocyte container which comprises an opening section, a side section and a bottom section and wherein the whole or part of the side section is provided with a portion having a horizontal cross section progressively increasing in the direction from the bottom section toward the opening section, centrifuging the container to accumulate the leukocytes in the bottom section, and counting the leukocytes thus accumulated.

  一种白细胞计数方法，包括在血小板制备溶液或红细胞制备溶液中加入细胞溶解剂，使血小板或红细胞溶解在白细胞容器中的相应溶液中，白细胞容器包括开口部分、侧面部分和底部部分、离心容器，使白细胞聚集在底部，并对聚集的白细胞进行计数。
• A method and a system for determination of particles in a liquid sample
  申请人：ChemoMetec A/S

  公开号：EP1180675A2

  公开（公告）日：2002-02-20

  The present invention relates to a method for the assessment of quantity and quality parameters of biological particles in a liquid analyte material. The method comprises applying a volume of a liquid sample to an exposing domain from which exposing domain electromagnetic signals from the sample in the domain can pass to the exterior, and exposing, onto an array of active detection elements such as CCD-elements, a spatial representation of electromagnetic signals having passed from the domain, the representation being detectable as an intensity by individual active detection elements, under conditions permitting processing of the intensities detected by the array of detection elements during the exposure in such a manner that representation of electromagnetic signals from the biological particles are identified as distinct from representations of electromagnetic signals from background signals. The size of the volume of the liquid sample is sufficiently large to permit the assessment of the quantity and quality parameters to fullfil a predetermined requirement to the statistical quality of the assessment based on substantially one exposure.

  本发明涉及一种评估液体分析材料中生物颗粒数量和质量参数的方法。该方法包括将一定量的液体样品置于一个曝光域中，来自该域中样品的电磁信号可从该曝光域传递到外部，并将从该域中传递的电磁信号的空间表象曝光到一个有源检测元件（如 CCD 元件）阵列上，该表象可作为强度被单个有源检测元件检测到，其条件是允许在曝光期间对检测元件阵列检测到的强度进行处理，以便将来自生物颗粒的电磁信号表象与来自背景信号的电磁信号表象区分开来。液体样品的体积足够大，以允许对数量和质量参数进行评估，从而满足对基于基本一次暴露的评估的统计质量的预定要求。
• Réactif et procédé pour l'identification et le comptage de cellules biologiques
  申请人：ABX

  公开号：EP1239283A1

  公开（公告）日：2002-09-11

  L'invention concerne un réactif et un procédé pour l'identification et le comptage de cellules biologiques dans un échantillon. Ce réactif comprend un agent de lyse cellulaire choisi parmi au moins un détergent en une concentration efficace pour lyser spécifiquement un type donné de cellules de l'échantillon, et un colorant propre à marquer les acides nucléiques intracellulaires des cellules restantes non lysées. Application notamment à l'identification et au comptage de cellules à partir d'un automate d'analyse basé sur la cytométrie de flux.

  本发明涉及一种用于识别和计数样品中生物细胞的试剂和方法。这种试剂包括一种细胞裂解剂，至少选自一种去污剂，其浓度能有效地特异性裂解样品中的特定类型细胞；还包括一种染料，适于标记剩余未裂解细胞的胞内核酸。特别适用于基于流式细胞仪的自动分析系统对细胞的识别和计数。