1-acrylamido-2-(2-pyridyl)ethane | 519164-52-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-acrylamido-2-(2-pyridyl)ethane
• 英文别名: 1-acryloamido-2-(2-pyridyl)ethane；N-[2-(pyridin-2-yl)ethyl]prop-2-enamide；N-(2-pyridin-2-ylethyl)prop-2-enamide
• CAS: 519164-52-4
• 化学式: C₁₀H₁₂N₂O
• 分子量: 176.218
• InChiKey: VJLRKARWSMXSNQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  42
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-acrylamido-2-(2-pyridyl)ethane 在 2,2'-azobisisobutyronitrile 、 HCl 、 KOH 作用下， 以 甲醇 、 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Polymer complexes.

  摘要：

  The build-up of polymer metallic supramolecules based on homopolymer (1-acrylamido-2-(2-pyridyl)ethane (AEPH)) and ruthenium, rhodium, palladium as well as platinum complexes has been pursued with great interest. The homopolymer shows three types of coordination behaviour. In the mixed valence paramagnetic trinuclear polymer complexes [(11)+(12)] in the paper and in mononuclear polymer complexes (1)-(5) it acts as a neutral bidentate ligand coordinating through the N-pyridine and NH-imino atoms, while in the mixed ligand diamagnetic poly-chelates, which are obtained from the reaction of AEPH with PdX2 and KPtCl4 in the presence of N-heterocyclic base consisting of polymer complexes (9)+(10), and in monouclear compounds (6)-(8), it behaves as a monobasic bidentate ligand coordinating through the same donor atoms. In mononuclear compounds (13)+(14) it acts as a monobasic and neutral bidentate ligand coordinating only through the same donor atoms. Monomeric distorted octahedral or trimeric chlorine-bridged, approximately octahedral structures are proposed for these polymer complexes. The poly-chelates are of 1:1, 1:2 and 3:2 (metal-homopolymer) stoichiometry and exhibit six coordination. The values of ligand field parameters were calculated. The homopolymer and their polymer complexes have been characterized physicochemically. (C) 2002 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s1386-1425(02)00222-6
• 作为产物：
  描述：

  2-(2-氨乙基)吡啶 、 丙烯酰氯 在 吡啶 、 对苯二酚 作用下， 以 苯 为溶剂， 生成 1-acrylamido-2-(2-pyridyl)ethane
  参考文献：
  名称：

  Polymer complexes.

  摘要：

  The build-up of polymer metallic supramolecules based on homopolymer (1-acrylamido-2-(2-pyridyl)ethane (AEPH)) and ruthenium, rhodium, palladium as well as platinum complexes has been pursued with great interest. The homopolymer shows three types of coordination behaviour. In the mixed valence paramagnetic trinuclear polymer complexes [(11)+(12)] in the paper and in mononuclear polymer complexes (1)-(5) it acts as a neutral bidentate ligand coordinating through the N-pyridine and NH-imino atoms, while in the mixed ligand diamagnetic poly-chelates, which are obtained from the reaction of AEPH with PdX2 and KPtCl4 in the presence of N-heterocyclic base consisting of polymer complexes (9)+(10), and in monouclear compounds (6)-(8), it behaves as a monobasic bidentate ligand coordinating through the same donor atoms. In mononuclear compounds (13)+(14) it acts as a monobasic and neutral bidentate ligand coordinating only through the same donor atoms. Monomeric distorted octahedral or trimeric chlorine-bridged, approximately octahedral structures are proposed for these polymer complexes. The poly-chelates are of 1:1, 1:2 and 3:2 (metal-homopolymer) stoichiometry and exhibit six coordination. The values of ligand field parameters were calculated. The homopolymer and their polymer complexes have been characterized physicochemically. (C) 2002 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s1386-1425(02)00222-6

文献信息

• Sulphones which modulate the action of gammasecretase
  申请人：Castro Pineiro Luis Jose

  公开号：US20070213329A1

  公开（公告）日：2007-09-13

  Novel sulphones of Formula I are disclosed: wherein A completes a 4-7 membered ring optionally comprising up to two heteroatoms. The compounds modulate the action of γ-secretase and are therefore useful in the treatment or prevention of Alzheimer's disease.

  公开了一种化学式为I的新型磺酰类化合物：其中A形成一个4-7环，可选地包含最多两个杂原子。这些化合物调节γ-分泌酶的作用，因此可用于治疗或预防阿尔茨海默病。
• Sulphones which modulate the action of gamma secretase
  申请人：Castro Pineiro Jose Luis

  公开号：US20090131419A1

  公开（公告）日：2009-05-21

  Disclosed are sulphones which modulate the action of gamma-secretase. The compounds are useful in the treatment or prevention of Alzheimer's disease.

  公开了可以调节γ-分泌酶作用的磺酰化合物。这些化合物对治疗或预防阿尔茨海默病有用。
• SULPHONES WHICH MODULATE THE ACTION OF GAMMA SECRETASE
  申请人：MERCK SHARP & DOHME LTD.

  公开号：EP1379498B1

  公开（公告）日：2011-02-16
• US7595344B2
  申请人：——

  公开号：US7595344B2

  公开（公告）日：2009-09-29
• US7598386B2
  申请人：——

  公开号：US7598386B2

  公开（公告）日：2009-10-06