7-硝基吲哚啉 | 100820-43-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: 7-硝基吲哚啉
• 英文名称: 7-nitroindoline
• 英文别名: 7-nitro-2,3-dihydro-1H-indole
• CAS: 100820-43-7
• 化学式: C₈H₈N₂O₂
• mdl: MFCD07371622
• 分子量: 164.164
• InChiKey: MSVCQAUKLQEIJJ-UHFFFAOYSA-N

物化性质

• 熔点：
  85-86 °C
• 沸点：
  308.2±31.0 °C(Predicted)
• 密度：
  1.298±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  57.8
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  7-硝基吲哚啉 以92%的产率得到
  参考文献：
  名称：

  SOMEI, MASANORI;YAMADA, FUMIO;HAMADA, HIROKAZU;KAWASAKI, TOSHIYA, HETEROCYCLES, 29,(1989) N, C. 643-648

  摘要：

  DOI：
• 作为产物：
  描述：

  1-acetyl-2,3-dihydro-7-nitroindole 、 sodium hydroxide 以96%的产率得到
  参考文献：
  名称：

  SOMEI, MASANORI;YAMADA, FUMIO;HAMADA, HIROKAZU;KAWASAKI, TOSHIYA, HETEROCYCLES, 29,(1989) N, C. 643-648

  摘要：

  DOI：

文献信息

• Synthesis and compositions of 2'-terminator nucleotides
  申请人：Bodepudi Veeraiah

  公开号：US20050037991A1

  公开（公告）日：2005-02-17

  The invention provides compositions the comprise nucleotides and/or nucleosides having blocking groups at 2′-positions of sugar moieties. Methods of synthesizing these nucleic acids are also provided.

  该发明提供了含有在糖基的2′-位置具有阻断基团的核苷酸和/或核苷的组合物。同时还提供了合成这些核酸的方法。
• PHOTOREACTIVE COLLAGEN-LIKE PEPTIDES
  申请人：Li Chunqiang

  公开号：US20190111132A1

  公开（公告）日：2019-04-18

  A novel 34 amino acid long collagen-like peptide rich in proline, hydroxyproline, and glycine, and with several photoreactive N-acyl-7-nitroindoline units incorporated into the peptide backbone was synthesized by on-resin fragment condensation. The circular dichroism measurement of this peptide supports a stable triple helix structure. This peptide has potential as a new biomimetic material with built-in latent photochemical functions that enable the decomposition into small peptide fragments by illumination with UV light of 350 nm. Using a photoreactive glycine derivative as a model compound for the collagen-like peptide, we demonstrate that its photolysis can also be triggered by a two-photon absorption process using a femtosecond laser at 710 nm. When a thin film of this compound is irradiated with femtosecond laser light at 710 nm the photochemistry occurs only at locations of irradiation. In addition, the collagen-like peptide is able to support mesenchymal stem cell growth, indicating its non-toxicity to these cells and its potential in tissue engineering applications.

  合成了一种含有34个氨基酸的胶原样肽，富含脯氨酸、羟脯氨酸和甘氨酸，并在肽骨架中引入了几个光反应性N-酰基-7-硝基吲哚单元。对该肽的圆二色性测量支持其稳定的三螺旋结构。这种肽具有潜力作为一种新的仿生材料，具有内置的潜在光化学功能，可以通过350纳米紫外光照射分解为小肽片段。使用光反应性甘氨酸衍生物作为胶原样肽的模型化合物，我们证明其光解也可以通过710纳米飞秒激光的双光子吸收过程触发。当这种化合物的薄膜被710纳米飞秒激光照射时，光化学反应仅发生在照射位置。此外，胶原样肽能够支持间充质干细胞的生长，表明其对这些细胞无毒，并在组织工程应用中具有潜力。
• [EN] MULTIPHOTON ACTIVABLE QUINOLINE DERIVATIVES, THEIR PREPARATION AND THEIR USES<br/>[FR] DÉRIVÉS DE QUINOLINE À ACTIVATION MULTIPHOTONIQUE, PRÉPARATION ET UTILISATIONS ASSOCIÉES
  申请人：CENTRE NAT RECH SCIENT

  公开号：WO2011086469A1

  公开（公告）日：2011-07-21

  The present invention relates to multiphoton activable organic compounds responding to the following formula (I). The present invention also relates to a method of synthesizing the compounds of the invention, to an aqueous solution comprising at least one compound of the invention, and to their specific uses. The present invention also concerns a method of liberating organic ligands, said method involving the step of irradiating a compound according to the invention.

  本发明涉及对以下公式（I）响应的多光子可激活有机化合物。本发明还涉及一种合成本发明化合物的方法，一种包含至少一种本发明化合物的水溶液，以及它们的特定用途。本发明还涉及一种释放有机配体的方法，该方法涉及辐照根据本发明的化合物的步骤。
• [EN] 7-NITROINDOLINE DERIVATIVES AND THEIR USES<br/>[FR] DERIVES DE 7-NITROINDOLINE ET LEURS UTILISATIONS
  申请人：MEDICAL RES COUNCIL

  公开号：WO2004085394A1

  公开（公告）日：2004-10-07

  7-nitroindoline compounds are disclosed that comprise a triplet sensitising group such as substituted or unsubstituted benzophenone group and can be used to cage effector species. In particular, the inclusion of a triplet sensitising group linked to the 4 or 5 position of a 7-nitroindoline derivative provides compounds which can be photolysed to release the effector species with unexpectedly enhanced photolysis efficiency. The triplet sensitising group may be linked directly to the 7-nitroindoline or via a spacer group. In some examples, the triplet sensitising group and/or the spacer group can be selected to enhance other properties of the caged compound such as its solubility, spectroscopic properties or stability (e.g. stability of the linkage between the nitroindoline moiety and the triplet sensitiser). This can help to improve the performance of the caged compound, especially in aqueous environments containing dissolved oxygen.

  本文介绍了一种包含三重敏化基团的7-硝基吲哚化合物，例如取代或未取代的苯基酮基团，并可用于封闭效应物种。特别是，将三重敏化基团连接到7-硝基吲哚衍生物的4或5位上，可提供可光解化合物，其光解效率意外增强，从而释放效应物种。三重敏化基团可以直接连接到7-硝基吲哚或通过间隔基团连接。在某些示例中，可以选择三重敏化基团和/或间隔基团以增强封闭化合物的其他性质，例如其溶解性，光谱性质或稳定性（例如硝基吲哚基团和三重敏化剂之间的连接的稳定性）。这有助于提高封闭化合物的性能，特别是在含有溶解氧的水环境中。
• [EN] INDOLINE COMPOUNDS AND DERIVATIVES AS EGFR INHIBITORS<br/>[FR] COMPOSÉS D'INDOLINE ET LEURS DÉRIVÉS EN TANT QU'INHIBITEURS D'EGFR
  申请人：BEIGENE LTD

  公开号：WO2022063106A1

  公开（公告）日：2022-03-31

  Provided are novel pharmaceutically active compounds and their preparation methods. The compounds inhibit mutant EGFR and are useful in the treatment of oncological diseases.

  提供了新型药物活性化合物及其制备方法。这些化合物能够抑制突变型EGFR，并且在肿瘤疾病的治疗中非常有用。