Boc-D-Me2Aoc-OH | 1070433-30-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Boc-D-Me2Aoc-OH
• 英文别名: (2R)-2-[methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]octanoic acid
• CAS: 1070433-30-5
• 化学式: C₁₄H₂₇NO₄
• 分子量: 273.373
• InChiKey: KRBBDQKDNCPZPM-LLVKDONJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  19
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  66.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Boc-D-Me2Aoc-OH 、 β-OH-D-leucine ethyl ester 在 N,N-二异丙基乙胺 、 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 以45%的产率得到
  参考文献：
  名称：

  Whole Structure−Activity Relationships of the Fat-Accumulation Inhibitor (−)-Ternatin: Recognition of the Importance of Each Amino Acid Residue

  摘要：

  A series of Ala and Aoc analogues of (-)-ternatin were prepared, and their bioactivities were assessed by a fat-accumulation inhibition assay using 3T3-L1 adipocytes, which led to the discovery of key structure-activity relationships (SAR).

  DOI：

  10.1021/jm800741n
• 作为产物：
  描述：

  N-tert-butoxycarbonyl-D-2-aminooctanoic acid 、 碘甲烷 在 sodium hydride 作用下， 以 四氢呋喃 、 mineral oil 为溶剂， 生成 Boc-D-Me2Aoc-OH
  参考文献：
  名称：

  Whole Structure−Activity Relationships of the Fat-Accumulation Inhibitor (−)-Ternatin: Recognition of the Importance of Each Amino Acid Residue

  摘要：

  A series of Ala and Aoc analogues of (-)-ternatin were prepared, and their bioactivities were assessed by a fat-accumulation inhibition assay using 3T3-L1 adipocytes, which led to the discovery of key structure-activity relationships (SAR).

  DOI：

  10.1021/jm800741n

文献信息

• Whole Structure−Activity Relationships of the Fat-Accumulation Inhibitor (−)-Ternatin: Recognition of the Importance of Each Amino Acid Residue
  作者：Kenichiro Shimokawa、Yoshiaki Iwase、Ryoka Miwa、Kaoru Yamada、Daisuke Uemura

  DOI：10.1021/jm800741n

  日期：2008.10.9

  A series of Ala and Aoc analogues of (-)-ternatin were prepared, and their bioactivities were assessed by a fat-accumulation inhibition assay using 3T3-L1 adipocytes, which led to the discovery of key structure-activity relationships (SAR).