methyl 5-methoxy-2-<5-methoxy-2-phenyloxazol-4-yl>oxazole-4-carboxylate | 146377-60-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: methyl 5-methoxy-2-<5-methoxy-2-phenyloxazol-4-yl>oxazole-4-carboxylate
• 英文别名: Methyl 5-methoxy-2-(5-methoxy-2-phenyl-1,3-oxazol-4-yl)-1,3-oxazole-4-carboxylate
• CAS: 146377-60-8
• 化学式: C₁₆H₁₄N₂O₆
• 分子量: 330.297
• InChiKey: JISHSAUOTKXSMP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  96.8
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  methyl 5-methoxy-2-<5-methoxy-2-phenyloxazol-4-yl>oxazole-4-carboxylate 以62%的产率得到
  参考文献：
  名称：

  Doyle Kevin J., Moody Christopher J., Tetrahedron, 50 (1994) N 12, S 3761-3772

  摘要：

  DOI：
• 作为产物：
  描述：

  2-叠氮丙二酸二甲酯 、 5-methoxy-2-phenyl-1,3-oxazole-4-carbonitrile 在 Rh₂(CF₃CONH)₄ 作用下， 以 氯仿 为溶剂， 以53%的产率得到methyl 5-methoxy-2-<5-methoxy-2-phenyloxazol-4-yl>oxazole-4-carboxylate
  参考文献：
  名称：

  Diazo-sulfones and -nitriles in oxazole synthesis; three step preparation of a bis-oxazole

  摘要：

  Oxazole-4-sulfones and -nitriles are prepared by rhodium(II) catalysed addition of nitriles to the corresponding diazo compound: the 4-cyarkooxazole 3 is readily converted into the bis-oxazoles 4 and S.

  DOI：

  10.1016/0040-4039(93)88041-g

文献信息

• Diazo-sulfones and -nitriles in oxazole synthesis; three step preparation of a bis-oxazole
  作者：Kevin J. Doyle、Christopher J. Moody

  DOI：10.1016/0040-4039(93)88041-g

  日期：1992.12

  Oxazole-4-sulfones and -nitriles are prepared by rhodium(II) catalysed addition of nitriles to the corresponding diazo compound: the 4-cyarkooxazole 3 is readily converted into the bis-oxazoles 4 and S.
• Doyle Kevin J., Moody Christopher J., Tetrahedron, 50 (1994) N 12, S 3761-3772
  作者：Doyle Kevin J., Moody Christopher J.

  DOI：——

  日期：——
• The rhodium carbenoid route to oxazoles. Synthesis of 4-functionalised oxazoles; Three step preparation of a bis-oxazole
  作者：Kevin J. Doyle、Christopher J. Moody

  DOI：10.1016/s0040-4020(01)90396-5

  日期：1994.3

  Oxazole-4-sulfones, -phosphonates, and -nitriles are prepared by rhodium(II) catalysed addition of nitriles to the corresponding diazo compound, The effect of the ligand on rhodium was briefly investigated, with rhodium(II) trifluoroacetamide generally proving the most effective catalyst. The 4-cyanooxazole 9 is readily converted into the bis-oxazoles 10-12.