2-<2-(4-Methylphenyl)-4-methoxyphenyl>-4,4-dimethyl-2-oxazoline | 149554-44-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-<2-(4-Methylphenyl)-4-methoxyphenyl>-4,4-dimethyl-2-oxazoline
• 英文别名: 2-(5-methoxy-4′-methyl[1,1′-biphenyl]-2-yl)-4,4-dimethyl-4,5-dihydrooxazole；2-[4-methoxy-2-(4-methylphenyl)phenyl]-4,4-dimethyl-5H-1,3-oxazole
• CAS: 149554-44-9
• 化学式: C₁₉H₂₁NO₂
• 分子量: 295.381
• InChiKey: ZKANKSWDHJWGCB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  30.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-<2-(4-Methylphenyl)-4-methoxyphenyl>-4,4-dimethyl-2-oxazoline 在 氢氧化钾 、 sodium hydroxide 、 PPA 、 一水合肼 、 sodium sulfate 、 mercury(II) oxide 、 碘甲烷 作用下， 以 四氢呋喃 为溶剂， 反应 54.75h， 生成 9-Diazo-6-methoxy-2-methyl-9H-fluorene
  参考文献：
  名称：

  Synthesis of substituted fluorenones and substituted 3',3'-dichlorospiro[fluorene-9,2'-thiiranes] and their reactivities

  摘要：

  Several novel 9-fluorenones were synthesized and were used as precursors in an attempt to prepare unique substituted 3',3'-dichlorospiro[fluorene-9,2'-thiiranes]. Several of the thiiranes were unstable and desulfurized during their preparation (7a-d,11,12). 3',3'-Dichloro(2,5-dimethoxyspiro[fluorene-9,2'-thiirane] (7f) was prepared along with 2,2-dichloro-3,3-bis(4-methoxyphenyl)thiirane (16), and 3',3'-dichloro-10,11-dihydrospiro[5H-dibenzo[a,d]cycloheptane-5,2'-thiirane] (17) all of which were stable at room temperature. A study of the reactivity of fluorenyl-substituted thiiranes and other related thiiranes showed that the extent of aromaticity of the substituents at the 3-position of the thiiranes influences their stabilities.

  DOI：

  10.1021/jo00068a039
• 作为产物：
  描述：

  2,4-二甲氧基苯甲酸 在 氯化亚砜 作用下， 反应 24.0h， 生成 2-<2-(4-Methylphenyl)-4-methoxyphenyl>-4,4-dimethyl-2-oxazoline
  参考文献：
  名称：

  Synthesis of substituted fluorenones and substituted 3',3'-dichlorospiro[fluorene-9,2'-thiiranes] and their reactivities

  摘要：

  Several novel 9-fluorenones were synthesized and were used as precursors in an attempt to prepare unique substituted 3',3'-dichlorospiro[fluorene-9,2'-thiiranes]. Several of the thiiranes were unstable and desulfurized during their preparation (7a-d,11,12). 3',3'-Dichloro(2,5-dimethoxyspiro[fluorene-9,2'-thiirane] (7f) was prepared along with 2,2-dichloro-3,3-bis(4-methoxyphenyl)thiirane (16), and 3',3'-dichloro-10,11-dihydrospiro[5H-dibenzo[a,d]cycloheptane-5,2'-thiirane] (17) all of which were stable at room temperature. A study of the reactivity of fluorenyl-substituted thiiranes and other related thiiranes showed that the extent of aromaticity of the substituents at the 3-position of the thiiranes influences their stabilities.

  DOI：

  10.1021/jo00068a039

文献信息

• Unified Protocol for Cobalt-Catalyzed Oxidative Assembly of Two Aryl Metal Reagents Using Oxygen as an Oxidant
  作者：Lian-Yan Liao、Kun-Ming Liu、Xin-Fang Duan

  DOI：10.1021/acs.joc.5b01787

  日期：2015.10.16

  reaction of two aryl metal reagents is described. An equivalent amount of two aryl Grignard or lithium reagents, after mediation by an equivalent amount of simple ClTi(OEt)3, was facilely assembled under the catalysis of 1 mol % of CoCl2/10 mol % of DMPU using oxygen. The cross-couplings between various aryl metal reagents, especially between two structurally similar aryl Grignard reagents, proceeded smoothly

  描述了两种芳基金属试剂的首次钴催化的氧化交叉偶联反应。通过简单的将ClTi（OET）等量的两个芳基或格利雅试剂锂等量，调停后3，1摩尔％的氯化钴的催化下轻便组装2使用氧气/ 10％（摩尔）的DMPU。各种芳基金属试剂之间，特别是两种结构相似的芳基格氏试剂之间的交叉偶联，可以平稳，选择性地进行，因此提供了一种构建联芳基化合物的高度通用且有效的方法。