4-carboethoxy-2,2-dimethyl-5-phenyl-3-penten-5-olide | 144467-66-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: 4-carboethoxy-2,2-dimethyl-5-phenyl-3-penten-5-olide
• 英文别名: ethyl 5,5-dimethyl-6-oxo-2-phenyl-2H-pyran-3-carboxylate
• CAS: 144467-66-3
• 化学式: C₁₆H₁₈O₄
• 分子量: 274.317
• InChiKey: BQZOZFZSSAHXQG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-甲氧基-1-(三甲基甲硅氧基)-2-甲基-1-丙烯 、 苯甲醛 、 丙炔酸乙酯 在 四氯化钛 、 dioxide titanium 作用下， 生成 4-carboethoxy-2,2-dimethyl-5-phenyl-3-penten-5-olide 、 (Z)-ethyl 4-carbomethoxy-2-(chlorobenzyl)-4-methyl-2-pentenoate
  参考文献：
  名称：

  Preparation and reactivity of the adducts of ketene alkylsilyl acetals with ethyl propiolate in the presence of titanium tetrachloride

  摘要：

  The reaction of ketene alkylsilyl acetals with ethyl propiolate in the presence of TiCl4 led to intermediates whose reactivity was studied with electrophiles such as H2O, D2O, NBS, NCS, and PhSeCl to form glutaconate derivatives. Except in the case of the dimethylketene trimethylsilyl acetal, for which the reaction was stereospecific, with other ketene acetals the selectivity was lower. Similar results were observed in the reaction of these titanium intermediates with aldehydes and ketones. The results were interpretated as the formation of vinylic titanium intermediates (more stabilized in the case of the dimethylketene acetal) in equilibrium with the titanium allenolates.

  DOI：

  10.1021/jo00051a039

文献信息

• Preparation and reactivity of the adducts of ketene alkylsilyl acetals with ethyl propiolate in the presence of titanium tetrachloride
  作者：Alain Quendo、Syed Massarat Ali、Gerard Rousseau

  DOI：10.1021/jo00051a039

  日期：1992.12

  The reaction of ketene alkylsilyl acetals with ethyl propiolate in the presence of TiCl4 led to intermediates whose reactivity was studied with electrophiles such as H2O, D2O, NBS, NCS, and PhSeCl to form glutaconate derivatives. Except in the case of the dimethylketene trimethylsilyl acetal, for which the reaction was stereospecific, with other ketene acetals the selectivity was lower. Similar results were observed in the reaction of these titanium intermediates with aldehydes and ketones. The results were interpretated as the formation of vinylic titanium intermediates (more stabilized in the case of the dimethylketene acetal) in equilibrium with the titanium allenolates.