2,6-Bis[(3-bromophenyl)methoxy]-5-hydroxy-7-phenyl-chromen-4-one | 1458714-83-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 2,6-Bis[(3-bromophenyl)methoxy]-5-hydroxy-7-phenyl-chromen-4-one
• 英文别名: 2,6-bis[(3-bromophenyl)methoxy]-5-hydroxy-7-phenylchromen-4-one
• CAS: 1458714-83-4
• 化学式: C₂₉H₂₀Br₂O₅
• 分子量: 608.283
• InChiKey: FMGBTEFCAFFHFD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.9
• 重原子数：
  36
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  65
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  5,6-dimethoxy-2-(methylthio)-7-phenyl-4H-chromen-4-one 在 aluminum (III) chloride 、 sodium hydride 、 potassium carbonate 、 间氯过氧苯甲酸 作用下， 以 四氢呋喃 、 丙酮 、 甲苯 、 mineral oil 为溶剂， 生成 2,6-Bis[(3-bromophenyl)methoxy]-5-hydroxy-7-phenyl-chromen-4-one
  参考文献：
  名称：

  Synthesis and Anti-HCV Activity of 2,6-Bisarylmethyloxy-5-hydroxy-7-phenylchromones

  摘要：

  6-bis(arylmethyloxy)-5-hydroxy-7-phenylchromone derivatives (3) with various metaor paraelectron withdrawing aromatic substituents (R = F, Cl, Br, I, CN, NO2, CF3) and evaluation of their anti-HCV activities. The synthetic route to the title compounds, 2,6-bis(arylmethyloxy)-5-hydroxy-7-phenylchromes (3a-3k) is outlined in Scheme 1. Following our previous protocols, 1-[5-hydroxy-2,3-dimethoxy-(1,1'-biphenyl)-4-yl]ethanone

  DOI：

  10.5012/bkcs.2013.34.7.1953

文献信息

• Synthesis and Anti-HCV Activity of 2,6-Bisarylmethyloxy-5-hydroxy-7-phenylchromones
  作者：Seoyoung Cho、Chaewoon Lee、Youhoon Chong

  DOI：10.5012/bkcs.2013.34.7.1953

  日期：2013.7.20

  6-bis(arylmethyloxy)-5-hydroxy-7-phenylchromone derivatives (3) with various metaor paraelectron withdrawing aromatic substituents (R = F, Cl, Br, I, CN, NO2, CF3) and evaluation of their anti-HCV activities. The synthetic route to the title compounds, 2,6-bis(arylmethyloxy)-5-hydroxy-7-phenylchromes (3a-3k) is outlined in Scheme 1. Following our previous protocols, 1-[5-hydroxy-2,3-dimethoxy-(1,1'-biphenyl)-4-yl]ethanone