1-fluoro-1-(4'-methoxyphenyl)silacyclobutane | 251453-08-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-fluoro-1-(4'-methoxyphenyl)silacyclobutane
• 英文别名: 1-Fluoro-1-(4-methoxyphenyl)silacyclobutane；1-fluoro-1-(4-methoxyphenyl)siletane
• CAS: 251453-08-4
• 化学式: C₁₀H₁₃FOSi
• 分子量: 196.297
• InChiKey: AHVOZVDMVGSMNR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.22
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-fluoro-1-(4'-methoxyphenyl)silacyclobutane 、 碘苯 在 bis(η3-allyl-μ-chloropalladium(II)) 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 68.0h， 生成 联苯 、 4-甲氧基联苯 、 4,4-二甲氧基联苯
  参考文献：
  名称：

  Synthesis of Unsymmetrical Biaryls from Arylsilacyclobutanes

  摘要：

  [GRAPHICS]Aryl(fluoro)silacyclobutanes and aryl(chloro)silacyclobutanes have been found to undergo cross-coupling reactions with aryl iodides. The rate of reaction and extent of homocoupling were dramatically affected by the addition of ligands for the palladium catalyst. With (t-Bu)(3)P a wide range of electronically and structurally diverse unsymmetrical biaryls have been prepared in good to excellent yields.

  DOI：

  10.1021/ol991054k
• 作为产物：
  描述：

  1-氯-1-(4-甲氧基苯基)硅杂环丁烷 在 copper (II)-fluoride 作用下， 以 乙醚 为溶剂， 以72%的产率得到1-fluoro-1-(4'-methoxyphenyl)silacyclobutane
  参考文献：
  名称：

  Synthesis of Unsymmetrical Biaryls from Arylsilacyclobutanes

  摘要：

  [GRAPHICS]Aryl(fluoro)silacyclobutanes and aryl(chloro)silacyclobutanes have been found to undergo cross-coupling reactions with aryl iodides. The rate of reaction and extent of homocoupling were dramatically affected by the addition of ligands for the palladium catalyst. With (t-Bu)(3)P a wide range of electronically and structurally diverse unsymmetrical biaryls have been prepared in good to excellent yields.

  DOI：

  10.1021/ol991054k

文献信息

• Synthesis of Unsymmetrical Biaryls from Arylsilacyclobutanes
  作者：Scott E. Denmark、Zhicai Wu

  DOI：10.1021/ol991054k

  日期：1999.11.1

  [GRAPHICS]Aryl(fluoro)silacyclobutanes and aryl(chloro)silacyclobutanes have been found to undergo cross-coupling reactions with aryl iodides. The rate of reaction and extent of homocoupling were dramatically affected by the addition of ligands for the palladium catalyst. With (t-Bu)(3)P a wide range of electronically and structurally diverse unsymmetrical biaryls have been prepared in good to excellent yields.